中国中西医结合杂志2018，Vol.37Issue(11)：1325-1329,5.DOI:10.7661/j.cjim.201709014.221
215例湿热型强直性脊柱炎中药治疗数据挖掘及关联规则研究
Data Mining Research and Association Rules Analysis on 215 Cases of Damp-heat Type Ankylosing Spondylitis Treated by Chinese Medicine
摘要
Abstract
Objective To analyze the effect of Chinese medicine used by department of rheumatology,the First Affiliated Hospital of Anhui University of Chinese Medicine on immune inflammatory biomarkers and superoxide dismutase (SOD) in treating damp-heat type ankylosing spondylitis (AS) patients based on data mining technology and association rules analysis. Methods Data of damp-heat type AS hospitalized patients were retrospectively collected from June 2012 to June 2015 at department of rheumatology First Afficiated Hospital of Anhui University of Chinese Medicine, based on clinical data mining technology.The technology for complex networks was integrated to mine the core prescription. The effect on immune inflammatory biomarkers and SOD were analyzed by Aprior module in SPSS Clementine 12.0. Results (1) By analyzingthe herbal prescription, the core herbs of prescription were found as: Coix Seed, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae, Poria Cocos, Rhizoma Alismatis, Herba Taraxaci,Oldenlandia,Semen Pruni Persicae,Flos Carthami,Salvia Miltiorrhiza, Herba Siegesbeckiae, Radix Clematidis, Cortex Eucommiae, Rhizoma Cibotii and Radix Glycyrrhizae. Those herbals took up over 50％ in core prescription. The most commonly used in treatment were Pi invigorating herbals,which mainly distributed to Pi, Wei or Shen channel. (2) Which could find some high-related couplet medicines under the condition that the minimum confidence level was set at 60％ and the minimum support level 20％. Rhizoma Dioscoreae was high-related to C3,C4 when compatibility with Radix Angelicae Pubescentis and Cortex Phellodendri (the confidence coefficients were 85. 19％,93. 33％), and high-related to hsCRP when compatibility with Poria Cocos (the confidence coefficient was 78. 10％). Compatibility of Poria Cocos and Rhizoma Anemarrhenae was associated with IgA and IgG (the confidence coefficients were 83. 33％,91. 67％),and compatibility of Cortex Phellodendri and Semen Pruni Persicae was associated with ESR (the confidence coefficient was 85.71％). Compatibilities of Herba Siegesbeckiae with Herba Taraxaci and Radix Angelicae Pubescentis were high-related to SOD and WBC respectively (the confidence coefficients were 85. 71 ％,75. 93％). Furong Ointment and Xiaoyu Jiegu Powder which for external use had higher association degree with ESR, hs-CRP and SOD. Conclusions According to the analysis of the proportion of each herbal, our department proposed that the treatment of damp-heat type AS should mainly concentrate on regulating Pi, and also gave consideration to Gan and Shen. Thus immune inflammatory biomarkers and SOD could be relieved by internal medicine coordinated with external medicine, and rational compatibility of drugs, which had effect on dispelling wind and eliminating dampness, clearing heat and removing toxicity, promoting circulation and removing stasis.关键词
强直性脊柱炎/湿热型/关联规则/数据挖掘/免疫炎症Key words
ankylosing spondylitis/damp-heat type/association rules/data mining/immune inflammatory引用本文复制引用
黄旦,刘健,忻凌,张帆,宋倩,郭锦晨,周巧..215例湿热型强直性脊柱炎中药治疗数据挖掘及关联规则研究[J].中国中西医结合杂志,2018,37(11):1325-1329,5.基金项目
国家中医药重点学科中医痹病学建设项目(No.国中医药发[2009]30号) （No.国中医药发[2009]30号）
国家临床重点专科中医风湿病科建设项目(No.财社[2013]239号) （No.财社[2013]239号）
国家自然基金青年项目(No. 81403388) （No. 81403388）
安徽省重点实验室建设项目(No. 1306c083035) （No. 1306c083035）
安徽省科技攻关项目(No. 1604a0802085) （No. 1604a0802085）
安徽省自然基金项目(No. 1508085QH159) （No. 1508085QH159）
