高电压技术2018，Vol.44Issue(6)：1913-1921,9.DOI:10.13336/j.1003-6520.hve.20180529025
高频纳秒脉冲串作用下活体兔肌肉收缩剂量效应研究
Dose Effect of High Frequency Nanosecond Pulse Bursts on Muscle Contraction of Rabbit in Vivo
摘要
Abstract
In order to explore the dose effect of high frequency nanosecond pulse bursts on muscle contraction, we investigated the effect of 10 unipolar high frequency nanosecond pulse bursts with different electric field intensities (1 kV/cm, 4 kV/cm and 8 kV/cm), intra-burst frequencies (10 kHz, 100 kHz and 1 MHz) and intra-burst number of pulses (1, 10 and 100) on rabbit muscle contraction in vivo. High frequency nanosecond pulse bursts with different parameters were delivered to the surface skin of rabbit thighs biceps through plate electrode, and the intensity of muscle contraction was assessed using the acceleration signal measured by a three-axis acceleration sensor attached on the surface skin of the muscle. The results of time and frequency domain analysis of synthetic acceleration module value signal show that the peak value of the signal increases as the value of any of the three parameters increases, however, the spectral distributions of the signals are similar, mainly distributing below 60 Hz. The multivariate nonlinear regression analysis of the experimental results reveals that the peak value of the signal can be expressed as a function of the three parameters, which indicate that when the frequency of the applied pulse burst is relatively low, appropriate increase in the intra-burst number of pulses will not strengthen muscle contraction too much. However, the intra-burst number of pulses should be minimized to limit strength of muscle contraction as much as possible when the frequency within the applied pulse burst is relatively high.关键词
高频纳秒脉冲串/兔肌肉收缩/剂量效应/加速度信号/频谱分布Key words
high frequency nanosecond pulse bursts/rabbit muscle contraction/dose effect/acceleration signal/spectrum distribution引用本文复制引用
米彦,徐进,唐雪峰,卞昌浩,杨骐瑜,唐均英..高频纳秒脉冲串作用下活体兔肌肉收缩剂量效应研究[J].高电压技术,2018,44(6):1913-1921,9.基金项目
国家自然科学基金(51477022 （）
51321063) （）
中央高校基本科研业务费(106112015CDJZR158804).Project supported by National Natural Science Foundation of China(51477022, 51321063), Fundamental Research Funds for the Central Universities(106112015CDJZR158804). （106112015CDJZR158804）
