摘要
Abstract
Objective To investigate the influence of pramipexole dihydrochloride and butylphthalide on emotion and Hcy in patients with Parkinson's disease.Methods 104 patients with Parkinson's disease were chosen to research,and were divided into a control group and a research group randomly.The control group were treated with pramipexole dihydrochloride,and the research group with pramipexole dihydrochloride and butylphthalide.After the treatment,the clinical effects,Hcy,cognition function,and UPRDS were compared between the two group.Results The total effective rate was higher in the research group than in the control group,with a statistical difference (P ＜ 0.05).After the treatment,the HAMD scale scores of the two groups decreased,and the MMSE scale scores increased,with statistical differences from those before the treatrnent (P ＜ 0.05).After the treatment,the HAMD score was lower and the MMSE scale score was higher in the research group than in the control group,with statistical differences (P ＜ 0.05).After the treatment,the UPRDS score and plasma Hcy level of the two groups decreased,with statistical differences from those before the treatment (P ＜ 0.05).After the treatment,the UPRDS score and plasma Hcy level were lower in the research group than in the control group,with statistical differences (P ＜ 0.05).Conclusion Pramipexole dihydrochloride combined with butylphthalide for patients with Parkinson's disease can effectively improve the emotion,Hcy,and cognition function,and its clinical effect is better than pramipexole dihydrochloride.关键词
帕金森/盐酸普拉克索/丁苯酞/情绪/同型半胱氨酸Key words
Parkinson's disease/Pramipexole dihydrochloride/Butylphthalide/Emotion/Homocysteine
