中国临床药理学杂志2018，Vol.34Issue(19)：2245-2247,2251,4.DOI:10.13699/j.cnki.1001-6821.2018.19.001
糖蛋白Ⅱb/Ⅲa受体外显子基因多态性在中国心血管病患者和健康志愿者中的分布差异
Difference distribution of glycoprotein Ⅱb/Ⅲa receptor exon polymorphisms between Chinese cardiovascular patients and healthy population
摘要
Abstract
Objective To investigate the differences in distribution of Glycoprotein (GP)Ⅱb/Ⅲa receptor exon polymorphisms between Chi-nese cardiovascular patients and healthy population .Methods Based on our previous study of healthy volunteers , this study used the method of Sequenom Mass ARRAY?to detect the exon mutation sites of ITGI2B and ITGB3 which encoding GPⅡb/Ⅲa receptor and analyzed the differences in distribution between the two populations .Results Eighteen sites were detected.Three variants in the ITGA2B locus and fifteen variants in the ITGB3 locus were identified.The linkage relationships between single nucleotide polymorphisms (SNPs) in cardiovascular patients and healthy population were similar. The genotypes of ITGB3 rs112188890 (P<0.001), rs11871447 ( P <0.001 ), rs4634 ( P <0.05 ), and rs70940817 ( P<0.001 ) were significantly different between cardiovas-cular patients and healthy population.Conclusion There are multiple polymorphic sites in the exons of ITGI2B and ITGB3 in Chinese population.关键词
GPⅡb/Ⅲa受体/心血管病患者/健康人群/基因多态性Key words
glycoprotein Ⅱb/Ⅲa/cardiovascular patient/healthy Chinese population/genetic polymorphisms分类
医药卫生引用本文复制引用
张卓,向倩,龚艳君,胡琨,谢秋芬,王梓凝,崔一民..糖蛋白Ⅱb/Ⅲa受体外显子基因多态性在中国心血管病患者和健康志愿者中的分布差异[J].中国临床药理学杂志,2018,34(19):2245-2247,2251,4.基金项目
国家自然科学基金面上项目(81573504,81673509) （81573504,81673509）
北京市自然科学基金资助项目(7171012) （7171012）
