中国临床药理学杂志2018，Vol.34Issue(19)：2259-2261,2265,4.DOI:10.13699/j.cnki.1001-6821.2018.19.005
双歧杆菌乳杆菌三联活菌片联合拉克替醇散治疗肝硬化自发性细菌性腹膜炎的临床研究
Clinical trial of live combined bifidobacterium and lactobacillus tablets and lactitol powder in the treatment of liver cirrhosis with spontaneous bacterial peritonitis
摘要
Abstract
Objective To analyze the clinical effect of live combined bifidobacterium and lactobacillus tablets and lactitol powder in the treat-ment of spontaneous bacterial peritonitis of liver cirrhosis .Methods A total of 180 patients with cirrhosis and spontaneous bacterial peritonitis were randomly divided into control group and treatment group , 90 cases in each group.Control group was given routine antibiotic treatment . Treatment group were given live combined bifidobacterium and lactobacil-lus tablets 5 mg· d-1, lactitol powder 1 g· d -1on the basis of control group.All patients were treated for 2 weeks.After treatment, the clinical efficacy, clinical characterization and recovery of liver function in two groups were observed.Results The total efficacy in control group and treatment group were 44.44%( 40 cases/90 cases ) and 67.78%( 61 cases/90 cases), with significant difference (P<0.05).The disappearance time of abdominal pain in control group and treatment group were ( 9.03 ±0.56 ) and ( 7.23 ±0.28 ) h, the durations of diarrhea cessation were (4.96 ±0.18 ) and (2.56 ±0.26 ) d, the disappearance time of abdominal tenderness were (11.21 ±0.55 ) and (8.39 ±0.25) min, the time of body temperature return to normal were (7.54 ±0.25), (5.36 ±0.52)h, the ascites cultures negative start time were (9.36 ±0.60 ) and (7.69 ±0.36 ) d, all with significant differences (all P<0.05). After treatment, the levels of alanine aminotransferase ( ALT), total bilirubin ( TBIL) and albumin ( Alb) in two groups had significant differences compared with before treatment ; and there were significant differences between control group and treatment group (all P<0.05).There was 1 case of nausea in treatment group , and there were 2 cases of nausea and 2 cases of bloating in control group.The incidence of adverse drug reactions in treatment group and control group were 1.11%( 1 case/90 cases ), 4.44%( 4 cases/90 cases ), without significant difference ( P>0.05 ) . Conclusion The combination of live combined bifidobacterium and lactobacillus tablets and lactitol powder in the treatment patients with cirrhosis and spontaneous bacterial peritonitis has good clinical effect , which can significantly improve the prognosis of patients.关键词
双歧杆菌乳杆菌三联活菌片/拉克替醇散/自发性细菌性腹膜炎患者/肝硬化Key words
live combined bifidobacterium and lactobacillus tablets/lactitol powder/spontaneous bacterial peritonitis/cirrhosis分类
医药卫生引用本文复制引用
张瑜,田笑笑,胡新俊..双歧杆菌乳杆菌三联活菌片联合拉克替醇散治疗肝硬化自发性细菌性腹膜炎的临床研究[J].中国临床药理学杂志,2018,34(19):2259-2261,2265,4.基金项目
国家自然科学基金资助项目(81600512) （81600512）
