中国临床药理学杂志2018，Vol.34Issue(19)：2269-2272,4.DOI:10.13699/j.cnki.1001-6821.2018.19.008
阿米替林片联合匹维溴铵片治疗腹泻型肠易激综合征的临床研究
Clinical trial of amitriptyline tablets combined with pinaverium bromide tablets in the treatment of diarrhea type irritable bowel syndrome
摘要
Abstract
Objective To observe the efficacy of pinaverium bromide alone or in combination with amitriptyline in the treatment of diarrhea type irritable bowel syndrome ( IBS-D).Methods One hundred and twenty-five patients with IBS -D,aged 18 -65 years,in our hospital from June 2013 to June 2016 were randomly divided into control group (63 cases,treated with pinaverium bromide 50 mg,tid) and treatment group (62 cases, on the basis of control group ,treated with amitriptyline 25 mg,qd).The total effective rate,the stool property and state,and the quality of life were assessed by IBS -bowel symptom severity scale (IBS-BSS),IBS-defecation state questionnaire ( IBS-DSQ) and the IBS-quality of life questionnaire (IBS-QOL) before and 4 weeks after the treatment respectively.Results After treatment,the IBS-BSS efficacy of the control group and the treatment group were 61.90%(39 cases/63 cases) and 85.48%(53 cases/62 cases), respectively, and the di-fference were statistically significant ( P<0.01 ).Total IBS-BSS scores of the control group and the treatment group were (166.32 ±72.75 ), (112.98 ±81.84 )point,respectively;which was significantly decreased in the treatment group (P<0.01).The IBS-DSQ effective rates of the control group and the treatment group were 71.43%(45 cases/63 cases) and 91.94%(57 cases/62 cases),respectively;which was significantly increased in the treatment group than that in the control group (P<0.01).Moreover,the total IBS-QOL integrals were statistically increased in the two groups , with the treatment group more pronounced.Conclusion Pinaverium bromide in combination with amitriptyline could effectively relieve bowel symptoms,improve the stool property and the defecation frequency and thus improve their quality of life ,which has a certain clinical application value .关键词
阿米替林片/匹维溴铵片/腹泻型肠易激综合征/联合治疗Key words
amitriptyline/pinaverium bromide/irritable bowel syndrome with diarrhea/combined treatment分类
医药卫生引用本文复制引用
戴蕾,陈明显,傅睿,夏亮,费保莹,沈堂彪..阿米替林片联合匹维溴铵片治疗腹泻型肠易激综合征的临床研究[J].中国临床药理学杂志,2018,34(19):2269-2272,4.基金项目
国家自然科学基金资助项目(81302957) （81302957）
浙江省自然科学基金资助项目(LY17H270003) （LY17H270003）
浙江省"十三五"中医药(中西医结合)重点学科建设计划基金资助项目(2017-XK-A24) （中西医结合）
浙江省科技厅院所专项基金资助项目(2017F30044) （2017F30044）
浙江省中医药科技计划基金资助项目(2018ZA022) （2018ZA022）
浙江省医药卫生科技计划基金资助项目(2018KY326) （2018KY326）
