中国临床药理学杂志2018，Vol.34Issue(19)：2302-2305,4.DOI:10.13699/j.cnki.1001-6821.2018.19.017
雷公藤多苷对盐敏感性高血压小鼠肾损害的保护作用
Protective effect of multi -glycoside of Tripterygium wilfordii Hook.F. on salt-sensitive hypertension-induced renal injury in mice
摘要
Abstract
Objective To clarify the protective effect of multi -glyco-side of Tripterygium wilfordii Hook.F.( GTW) on salt-sensitive hyper-tension-induced renal injury in mice .Methods To establish salt -sensitive hypertension model ,the mice were subjected to uninephrectomy and deoxycorticosterone acetate (DOCA)-salt treatment.The mice were assigned into control group , model group and test group.The control group treated by uninephrectomy was gavaged with 0.9%NaCl;the model group treated by DOCA -salt was gavaged with 0.9%NaCl; the test group treated by DOCA-salt was gavaged with GTW 23 mg· kg-1· d-1. All of the three groups were continuously gavaged twice a day for 5 weeks.The excretion of urinary albumin and 8-isoprostane,creatinine clearance ,the changes in renal pathology and monocyte/macrophage infil-tration were compared among the three groups .Results After treat-ment, the excretion of urinary albumin for the test group , control group and model group were (22.49 ±3.97),(5.70 ±0.98) and (48.75 ±4.49) μg· 24 h-1;the excretion of 8-isopros-tane for the three groups were (1.84 ±0.30 ),(0.42 ±0.08 ) and (3.07 ±0.47 ) ng· 24 h -1;the creatinine clea-rance for the three groups were (245.02 ±27.86 ),(336.53 ±25.99 ) and(133.76 ±18.18 ) mL· 24 h -1;the glome-rulosclerosis index for the three groups were (0.27 ±0.06),(0.09 ±0.04)and (0.64 ±0.10);the tubulointerstitial injury score for the three groups were (1.25 ±0.29),(0.34 ±0.16)and (3.10 ±0.46);the renal F4/80 positive cells for the three groups were(18.84 ±5.36),(9.80 ±1.72) and (63.00 ±9.13)cell· mm-2.Compared with the test group and the control group ,the differences in all of the parameters described above in the model group were statis-tically significant(all P<0.05).Conclusion GTW could ameliorate renal injury in DOCA -salt hypertension via in-hibiting monocyte/macrophage infiltration.关键词
雷公藤多苷/盐敏感性高血压/肾损害/单核/巨噬细胞/炎症Key words
multi -glycoside of Tripterygium wilfordii Hook.F./salt -sensitive hypertension/renal injury/monocyte/macrophage/inflammation分类
医药卫生引用本文复制引用
刘素晓,宋纯东,崔琳,高原,谢世阳,沈思,朱明军,王幼平..雷公藤多苷对盐敏感性高血压小鼠肾损害的保护作用[J].中国临床药理学杂志,2018,34(19):2302-2305,4.基金项目
国家自然科学基金面上项目(81673734) （81673734）
河南省科技攻关计划课题资助项目(162102410048) （162102410048）
