中国临床药理学杂志2018，Vol.34Issue(19)：2306-2308,2312,4.DOI:10.13699/j.cnki.1001-6821.2018.19.018
决枳合剂治疗酒精性脂肪肝大鼠的实验研究
Experimental study of the mixture of cassia seed and hovenia dulcis thunb in the treatment of rats with alcoholic fatty liver
摘要
Abstract
Objective To explore the effects of the mixture of cassia seed and hovenia dulcis thunb on liver pathology , liver function and in-flammatory factors of rats with alcoholic fatty liver .Methods Alcoholic fatty liver model was established by intragastric administration of 56%al-cohol, and the model rats were randomly divided into model group , con-trol A group, control B group and test group .And the normal rats were set up as blank group.Blank group and model group were treated with 10 mL· kg-10.9% NaCl, qd.Control A group was given 1.5 g· mL-1 cassia seed at the dose of 10 mL· kg -1, qd.Control B group was given 1.5 g· mL-1hovenia dulcis thunb at the dose of 10 mL· kg -1, qd. Test group was given 1.5 g· mL -1mixture of cassia seed and hovenia dulcis thunb at the dose of 10 mL· kg -1, qd. Five groups were administrated by gavage for 4 weeks.The liver pathological results , alanine ami-notransferase (ALT), aspartate amin-otransferase (AST), nuclear factor-kappa B (NF-κB), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were compared between the five groups.Results The main indexes of blank, model, control A, control B and test groups were compared : liver inflammation activity score were (0.57 ±0.48 ), ( 3.71 ±0.85 ), ( 2.52 ±0.79 ), (2.37 ±0.81 ) and ( 1.61 ±0.67 ), ALT were ( 39.25 ±10.07 ), ( 89.37 ±14.53 ), ( 72.43 ±12.08 ), (70.17 ±13.56) and (51.26 ±11.57)U· L-1, AST were (34.14 ±4.95), (139.19 ±14.87), (90.00 ±17.57), (87.47 ±12.38 ) and ( 51.27 ±8.25 ) U· L-1, NF -κB were ( 265.45 ±47.12 ), ( 534.41 ±72.18 ), (387.15 ±60.29 ), ( 390.31 ±63.64 ) and ( 321.26 ±43.25 ) ng· L-1, TNF -α were ( 26.85 ±4.97 ), (89.78 ±9.86), (55.21 ±11.79), (57.32 ±9.63) and (40.24 ±9.47)nmol· L-1, IL-6 were (12.13 ±5.86), (69.34 ±12.79), (43.16 ±10.62), (46.28 ±11.57) and (24.47 ±10.84)pg· mL-1, the differences were statis-tically significant between test group and other four groups ( all P<0.05 ).Conclusion The mixture of cassia seed and hovenia dulcis thunb could obviously improve the pathological changes of liver tissue and liver function , and also could reduce the expression of inflammatory factors in rats with alcoholic fatty liver disease .关键词
决枳合剂/决明子/枳椇子/酒精性脂肪肝Key words
mixture of cassia seed and hovenia dulcis thunb/cassia seed/hovenia dulcis thunb/alcoholic fatty liver分类
医药卫生引用本文复制引用
邹碧泉,朱小区..决枳合剂治疗酒精性脂肪肝大鼠的实验研究[J].中国临床药理学杂志,2018,34(19):2306-2308,2312,4.基金项目
浙江省中医药科技计划课题资助项目(2008YA027) （2008YA027）
