中国临床药理学杂志2018，Vol.34Issue(19)：2345-2347,3.DOI:10.13699/j.cnki.1001-6821.2018.19.029
肾病综合征患者个体化应用他克莫司的病例分析
Case analysis of individualized tacrolimus treatment on patient with nephrotic syndrome
摘要
Abstract
Objective To combine genotyping and therapeutic drug mo-nitoring ( TDM ) and to provide patients with reasonable treatment . Methods Clinical pharmacists were able to participate in the treatment of 1 patient with nephrotic syndrome ,analyze the causes of poor efficacy in the early stage of hospitalization , combine the genotyping result and remind the clinicians to adapt an appropriate drug dose ,or use a combi-nation of drugs to improve drug plasma concentration .It is recommended to monitor the plasma drug concentration of tacrolimus and develop ration-al use of immunosuppressant drugs .Results and conclusion The pa-tient's tacrolimus concentration quickly reached the standard and his condition improved.The patient was discharged.In clinical practice, pharmacists should combine the patient's diseases, medications, geno-types and other factors, with the use of drug interactions to increase plasma concentration of tacrolimus, save the patient's expenses, and fully use therapeutic drug monitoring and other means to improve the effectiveness of drug treatment and safety.关键词
基因检测/个体化用药/他克莫司/肾病综合征/治疗药物监测Key words
gene detection/individuallized medication/tacrolimus/nephrotic syndrome/therapeutic drug therapy分类
医药卫生引用本文复制引用
张晓丹,解染,崔一民..肾病综合征患者个体化应用他克莫司的病例分析[J].中国临床药理学杂志,2018,34(19):2345-2347,3.基金项目
国家重点研发计划精准医学研究重点专项资助项目(2016YFC0904900) （2016YFC0904900）
