中国临床药理学杂志2018，Vol.34Issue(19)：2376-2379,4.DOI:10.13699/j.cnki.1001-6821.2018.19.037
非临床甲状腺C细胞毒性的案例分析
Case analysis of non-clinical study of thyroid C cells toxicity
尹华静 1尹茂山 1王寅 1吴爽 1李铮 1胡晓敏1
作者信息
- 1. 国家食品药品监督管理总局 药品审评中心,北京 100022
- 折叠
摘要
Abstract
To explore the correlation between animal data that demonstra-ted potential thyroid C cells toxicity in non -clinical carcinogenicity stud-ies and clinical safety , in order to provide the basis for the non -clinical safety evaluation and clinical risks control .Summarized and untangled the carcinogenicity data and safety range of marketed drugs which could induce thyroid C cells tumors in non -clinical carcinogenicity studies , and analyszed the basis for approval .The correlation between animal thyroid C cells toxicity and human should be further studied .关键词
甲状腺C细胞/胰高血糖素样肽-1受体激动剂/致癌性试验/甲状腺髓样癌Key words
thyroid C cells/glucagon -likepeptide1 receptor agonists/carcinogenicity study/medullary thyroid carcinoma分类
医药卫生引用本文复制引用
尹华静,尹茂山,王寅,吴爽,李铮,胡晓敏..非临床甲状腺C细胞毒性的案例分析[J].中国临床药理学杂志,2018,34(19):2376-2379,4.
