中国现代手术学杂志2018，Vol.22Issue(4)：311-315,5.DOI:10.16260/j.cnki.1009-2188.2018.04.018
不同浓度罗哌卡因联合舒芬太尼应用于硬膜外分娩镇痛的效果分析
Effects of Different Concentrations of Ropivacaine and Sufentanil in Epidural Labor Analgesia
摘要
Abstract
Objective To investigate the effect of different concentrations of ropivacaine combined with sufentanil for epidural labor analgesia. Methods 200 cases of single birth full-term primiparas were select-ed, and were randomly divided into group A , group B, group C, and group D, with 50 cases in each.Patients received 0.075%, 0.1%, 0.125%, and 0.15% ropivacaine combined with 5 μg/ml sufentanil in the group A, B, C, and D respectively.The patients in the four groups were treated with epidural extradural injection. And among the four groups , it was compared in analgesic time , the visual analogue scale (VAS), the Bromage score, time of labor and the occurrence of adverse reactions. Results Analgesic onset time of group D was the shortest (P＜0.05), and analgesic onset time of group C was also significantly shorter than that of group A and group B (P＜0.05).The dosing interval of group C and group D was significantly longer than that of group A and group B ( P＜0.05).The interval number of group C and group D was significantly less than that of group A and group B (P＜0.05).Maintenance time of the initial dose of group C and group D was significantly longer than that of group A and group B (P＜0.05).There was no significant difference in VAS scores among the four groups when the analgesia starting, 10 minutes and 30 minutes after analgesia, and womb full open-ing (P＞0.05).The incidence of motor block in group A and group B was significantly less than that in group D (P＜0.05), and the degree of motor block in group C was slightly less than that in group D, but there was no significant difference between the two groups ( P＞0.05).The first stage of labor in group A and B was significantly shorter than that in group C and D (P＜0.05), but there was no significant difference be-tween group A and group B ( P＞0.05).And there was no significant difference between group C and group D ( P＞0.05).There was no statistically significant difference in the second and the third stage of labor a-mong the four groups ( P＞0.05).The total incidence of adverse reactions in group D was significantly high-er than that in the other three groups ( P＜0.05), and there was no significant difference among group A, group B and group C (P＞0.05). Conclusion It is recommended of 0.125%ropivacaine combined with 0.5 μg/ml sufentanil for epidural labor analgesia with quick onset, good analgesic effects, fewer side effects, and higher safety.关键词
罗哌卡因/舒芬太尼/分娩镇痛Key words
ropivacaine/sufentanil/labor analgesia分类
医药卫生引用本文复制引用
谭瑛,梁曼,张贻岚,罗丹..不同浓度罗哌卡因联合舒芬太尼应用于硬膜外分娩镇痛的效果分析[J].中国现代手术学杂志,2018,22(4):311-315,5.基金项目
四川省卫生和计划生育委员会科研课题(编号:16PJ078) （编号:16PJ078）
