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Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

Kevin P. Kent Chad E. Schroeder Chandana Sharma

药物分析学报(英文)2018,Vol.8Issue(5):302-306,5.
药物分析学报(英文)2018,Vol.8Issue(5):302-306,5.

Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation

Kevin P. Kent 1Chad E. Schroeder 1Chandana Sharma1

作者信息

  • 1. Upstream R&D, MilliporeSigma, 13804 W 107th St, Lenexa, KS 66215, USA
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摘要

关键词

Monoclonal antibodies/Freeze–thaw/Protein aggregation/Protein stability

Key words

Monoclonal antibodies/Freeze–thaw/Protein aggregation/Protein stability

引用本文复制引用

Kevin P. Kent,Chad E. Schroeder,Chandana Sharma..Solution pH jump during antibody and Fc-fusion protein thaw leads to increased aggregation[J].药物分析学报(英文),2018,8(5):302-306,5.

药物分析学报(英文)

OASCI

2095-1779

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