陕西中医2018，Vol.39Issue(11)：1501-1503,1514,4.DOI:10.3969/j.issn.1000-7369.2018.11.003
外用芍药苷对银屑病小鼠的治疗作用研究
Effects of paeoniflorin as topical therapy on psoriasis-like mouse model
摘要
Abstract
Objective :To illustrate the effects of paeoniflorin as topical therapy on psoriasis-like mouse mod-el.Methods :BALB/c mice were randomly assigned to four groups including control group ,IMQ-induced group , IMQ accompanied with low-dose paeoniflorin treatment ,and IMQ accompanied with high-dose paeoniflorin treat-ment .Shaved mouse dorsal skin of three groups was treated daily with Aldara cream and one control group with Vaseline for seven days .Two experimental groups of mice also received topical treatment with paeoniflorin .Mice were sacrificed on the seventh day and skin samples were collected for subsequent phenotype analysis and HE stai-ning .Results :The results showed that the erythema scales and the epidermis thickness of ears were significantly re-duced after topical treatment of paeoniflorin in IMQ-induced mice .HE staining also showed a significant decrease in the number of dermal infiltrating lymphocytes ,and the paeoniflorin treatment exhibited a dose-dependent therapeutic effect ,suggesting that topical paeoniflorin could inhibit the inflammatory responses of psoriasis and alleviate the pso-riasis symptoms .Conclusion :Topical paeoniflorin alleviates the psoriasis-like inflammation in mouse model ,which indicates that Paeoniflorin can be further developed and clinically applied as a targeted therapy for psoriasis .关键词
银屑病/中医药疗法/芍药苷/治疗应用/动物实验/小鼠Key words
Psoriasis/traditional Chinese medicine therapy/Paeoniflorin/therapeutic uses/Animal experi-mentation/Mice分类
医药卫生引用本文复制引用
俞晨,白小翠,党二乐,王刚..外用芍药苷对银屑病小鼠的治疗作用研究[J].陕西中医,2018,39(11):1501-1503,1514,4.基金项目
国家临床重点专科建设项目陕西省科技计划项目(2016LCZX-06 （）
2016SF-374)陕西省科技统筹创新工程计划项目(2016KTZDSF02-05) （2016KTZDSF02-05）
