陕西中医2018，Vol.39Issue(11)：1521-1523,3.DOI:10.3969/j.issn.1000-7369.2018.011.009
脉血康胶囊与依达拉奉联合治疗对出血性脑梗死患者血清MMP-9、S100β蛋白水平和神经功能的影响
The Influences of Maixuekang capsule combined edaravoneon in serum MMP-9 ,S-100β protein levels and nerve function in patients with hemorrhagic cerebral infarction
摘要
Abstract
Objective :To investigate the effect of Maixuekang capsule combined edaravone on hemorrhagic cerebral infarction patients and its influences on serum matrix metalloproteinase-9 (MMP-9) ,S-100β protein levels and nerve func-tion.Methods :76 cases of hemorrhagic cerebral infarction patients were selected as the research subjects ,they were ran-domly divided into two groups .The control group was given Edaravone ,and the treatment group was treated with Maixuek-ang capsule on the basis of the control group .The clinical efficacy ,serum MMP-9 and S-100β protein levels ,nerve function recovery ,activity of daily living and incidence rate of adverse reactions were compared between the two groups .Results :The total effective rate of the treatment group was 92 .11%,which was higher than 71.05% of the control group (P＜0.05) ;the National Institutes of Health Stroke Scale (NIHSS) score in the two groups decreased ,and the Activity of Daily Living Scale (ADL) score increased ,the improvement of the two scores in the treatment group was better than that in the control group (P＜0 .05) ;the levels of MMP-9 and S-100 data in the two groups were lower than those before treatment on the 7th and 14th day after treatment (P＜0.05) ,and the treatment group was lower than the control group at all time points (P＜0.05) ;at third day after treatment ,the levels of S-100β in the two groups were all higher than those before treatment (P＜0.05) ;there was no significant difference in the incidence of adverse reactions between the two groups (P＞0 .05).Conclu-sion :The combination of Maixuekang capsule and edaravone is effective in treating hemorrhagic cerebral infarction ,it can significantly improve nerve function defect and daily living ability ,reduce serum MMP-9 and S-100β protein levels ,and has higher safety .关键词
脑梗塞/中医药疗法/@依达拉奉/@脉血康胶囊Key words
Brain infarction/traditional Chinese medicine therapy/＠Edaravoneon/＠Maixuekang capsule分类
医药卫生引用本文复制引用
张建强,焦永平..脉血康胶囊与依达拉奉联合治疗对出血性脑梗死患者血清MMP-9、S100β蛋白水平和神经功能的影响[J].陕西中医,2018,39(11):1521-1523,3.基金项目
河南省自然科学基金资助项目(162300410103) （162300410103）
