陕西中医2018，Vol.39Issue(11)：1592-1595,4.DOI:10.3969/j.issn.1000-7369.2018.11.030
雷公藤多苷联合免疫抑制剂治疗肾病综合征临床研究
Clinical efficacy of tripterygium glycosides combined with immunosuppressive agents in the treatment of nephrotic syndrome
摘要
Abstract
Objective :To investigate the clinical efficacy and safety of tripterygium glycosides combined with immu-nosuppressive agents in the treatment of nephrotic syndrome .Methods :72 patients with nephrotic syndrome admitted were selected as the research subjects .They were divided into control group and observation group by random number table grouping method ,36 cases in each group .All patients underwent basic treatment such as kidney protection ,hypotension , diuresis ,anticoagulation ,anti infection ,low salt and low protein diet .The patients in the control group were treated with prednisone acetate tablets ,and the observation group was given tripterygium glycosides tablets on the basis of the control group.The serum BUN ,Scr ,ALB and 24 h urinary protein quantitation ,clinical efficacy and adverse reactions were com-pared between the two groups before and after treatment .Results :There was no significant difference in TCM syndrome scores between the two groups before treatment (P＞ 0 .05).After 2 ,4 ,6 months ,the TCM syndrome scores of the two groups were significantly decreased ,and the observation group was more obvious than the control group ,the difference was statistically significant (P＜ 0.05).There was no significant difference in the level of TC and TG before treatment in the two groups (P＞0 .05) ,and the levels of TC and TG decreased significantly in the two groups after treatment ,and the difference was statistically significant (P＜0.05).The level of TC and TG in the observation group was significantly lower than that of the control group (P＜0 .05).There was no significant difference in the quantitative comparison of serum BUN ,Scr ,ALB and 24 h urine protein before treatment (P＞0 .05).After treatment ,the serum ALB increased in the two groups ,BUN ,Scr and 24 h urine protein decreased (P＜0 .05) ,and the serum ALB was significantly higher than that of the control group after treatment .(P＜0 .05).The total effective rate of the observation group was 86.11%(31/36) , which was significantly higher than that of the control group (63 .89%(23/36) ,and the difference was statistically signifi-cant (P＜ 0.05).There was no significant difference in clinical adverse reactions between the two groups (P＞0.05). There was no significant difference in the quality of life scores between the two groups (P＞0.05) ,and the scores of the quality of life in the two groups after treatment in the two groups were significantly increased ,and there was a significant difference between the two groups after treatment (P＜0.05).Conclusion :The combination of Tripterygium wilfordii com-bined with immunosuppressant can significantly increase the level of serum ALB in patients with nephrotic syndrome ,reduce the quantity of TC ,TG ,BUN ,Scr and 24 h urine protein ,and improve the quality of life of the patients ,and the clinical efficacy is significant ,and safety .关键词
肾病综合征/中西医结合疗法/免疫抑制药/治疗应用/雷公藤/治疗应用Key words
Nephrotic syndrome/integrated Chinese traditional and western medicine therapy/Immuno-suppressive agents/therapeutic uses/Tripterygium wilfordii/therapeutic uses分类
医药卫生引用本文复制引用
赵静瑜,吴际,王乃平,赵盼..雷公藤多苷联合免疫抑制剂治疗肾病综合征临床研究[J].陕西中医,2018,39(11):1592-1595,4.基金项目
河南省医学科技攻关计划项目(201404038) （201404038）
