中国感染控制杂志2018，Vol.17Issue(11)：958-964,7.DOI:10.3969/j.issn.1671-9638.2018.11.003
发热伴血小板减少综合征神经系统受累患者的临床特征
Clinical characteristics of patients suffered from nervous system involved severe fever with thrombocytopenia syndrome
摘要
Abstract
Objective To analyze clinical characteristics of patients suffered from nervous system involved severe fever with thrombocytopenia syndrome (SFTS).Methods Clinical data of SFTS patients who were admitted to Qingdao Sixth People’s Hospital between January 2016 and December 2017 were retrospectively analyzed.Accor-ding to whether there was nervous system involvement,they were divided into two groups,clinical data of two groups of patients were compared and analyzed;SFTS patients with nervous system involvement were subdivided in-to death group and survival group according to the final outcome,clinical data of two groups were compared and ana-lyzed.Results The median date of occurrence of neurological symptoms in SFTS patients was at day 6 of disease process. There were statistical differences in age,skin ecchymosis/severe bleeding tendency,C-reactive protein,procalcitonin,Ca2+on admission,CD4+cell count,myocardial enzymes (LDH,CK,CKMB,HBDH),pulmonary inflammation,liver func-tion (ALT,Alb,AST),and activated partial thromboplastin time (APTT)between nervous system involvement group and non-nervous system involvement group(all P＜0.05).Among patients with nervous system involvement,there were statistical differences in skin ecchymosis,the lowest value of PLT,positive rate of SFTSV-IgM antibody,CD3+cell count, CD4+cell count,LDH,Alb,and APTT between death group and survival group (all P＜0.05).Conclusion Most SFTS patients with nervous system involvement are elderly patients with seriously damaged coagulation function, liver function,myocardial enzymes and immune system,proportion of pulmonary infection is high.Among SFTS patients with nervous system involvement,impairment of coagulation function,immune function,liver function, and myocardial enzymes in deceased patients are more serious than those in survivors.关键词
发热伴血小板减少综合征/脑炎/多器官功能损害/免疫紊乱Key words
severe fever with thrombocytopenia syndrome/encephalitis/multiple organ dysfunction/immune disorder分类
医药卫生引用本文复制引用
王宁,张伟,段建平,马艳丽,陈志海,范天利..发热伴血小板减少综合征神经系统受累患者的临床特征[J].中国感染控制杂志,2018,17(11):958-964,7.基金项目
十三五国家科技重大专项(2017ZX10305501005) （2017ZX10305501005）
北京市医院管理局临床技术创新项目(XMLX201502) （XMLX201502）
