中国感染控制杂志2018，Vol.17Issue(11)：969-973,5.DOI:10.3969/j.issn.1671-9638.2018.11.005
骨关节感染病原学及其临床特征的回顾性研究
Retrospective study on pathogens and clinical characteristics of osteoarti-cular infection
摘要
Abstract
Objective To analyze the distribution of main pathogens,antimicrobial susceptibility,and clinical characteristics of osteoarticular infection,and provide evidence for clinical treatment.Methods A retrospective sur-vey was conducted on clinical data and pathogenic results of hospitalized patients with osteoarticular infection diag-nosed by etiology and pathology in Peking University First Hospital from 2009 to 2016,surveyed data were analyzed statistically.Results A total of 99 cases of bacterial osteoarticular infection were enrolled,100 strains of pathogenic bacteria were isolated,gram-positive bacteria accounted for 67.00%,49.00% of which were Staphylococcus spp., Enterobacteriaceae bacteria accounted for 67.74% of 31 strains of gram-negative bacteria.Isolation rate of methicil-lin-resistant Staphylococcus aureus (MRSA)was 16.13%,resistance rates of Staphylococcus spp.to fluoroquino-lones and rifampicin were both lower than 30%.Complication with other site infection (urinary tract infection,in-testinal infection,bloodstream infection)was an independent risk factor for gram-negative bacterial steoarticular in-fection (P＝0.027,OR＝10.536,95% CI:1.300－85.417).Conclusion Staphylococcus spp.is still the main pathogen causing osteoarticular infection,proportion of MRSA is low.Patients with urinary tract infection and in-testinal infection as well as long duration of implant should be considered the possibility of gram-negative bacterial infection when they develop steoarticular infection.关键词
骨关节感染/葡萄球菌/植入物相关感染/耐药性/抗药性,微生物Key words
osteoarticular infection/Staphylococcus/implant-related infection/drug resistance,microbial分类
医药卫生引用本文复制引用
李湘燕,施学东,郑波..骨关节感染病原学及其临床特征的回顾性研究[J].中国感染控制杂志,2018,17(11):969-973,5.基金项目
国家科技支撑计划基金(2012EP001002) （2012EP001002）
