局解手术学杂志2018，Vol.27Issue(10)：693-698,6.DOI:10.11659/jjssx.05E018126
DEPTOR在直肠癌中的表达及对预后的影响
Expression and prognostic effect of DEPTOR in rectal carcinoma
王娟 1张朝阳 2邵志林 3闫国林 4张甜甜 5李燕 6钟春生1
作者信息
- 1. 蚌埠医学院附属蚌埠市第三人民医院肿瘤内科,安徽 蚌埠233000
- 2. 蚌埠医学院第一附属医院肿瘤外科,安徽 蚌埠 233004
- 3. 蚌埠医学院第一附属医院急诊外科,安徽 蚌埠233004
- 4. 蚌埠医学院第一附属医院胃肠外科,安徽 蚌埠233004
- 5. 蚌埠医学院第一附属医院肿瘤内科,安徽 蚌埠233004
- 6. 蚌埠医学院第一附属医院消化内科,安徽 蚌埠233004
- 折叠
摘要
Abstract
Objective To clarify the expression of DEPTOR in rectal cancer,and to further explore the relationship between the expres-sion level of DEPTOR and histopathology and prognosis,in order to provide reference for the clinical diagnosis and treatment of rectal cancer. Methods The clinical data of 102 patients who underwent radical resection of rectal cancer in our hospital from January 2011 to January 2013 were analyzed retrospectively.The expression of DEPTOR in cancer tissues and adjacent tissues were evaluated by immunohistochemis-try and immunoblotting.The patients were divided into high expression group and low expression group by the median value of integrated opti-cal density(IOD);the relationship between the expression level of DEPTOR and clinical,histopathology and prognosis was analyzed. Results The results ofImmunohistochemistry and immunoblotting showed that the expression level of DEPTOR in cancer tissues was higher than that in adjacent tissues,the differences were significant(P<0.05). Univariate analysis showed that there was no significant differences in gender, age,and BMI(P>0.05),and there were significant differences in tumor diameter,T stage,N stage,and differentiation between the high-ex-pression and low-expression group (P<0.05).The independent influencing factors of DEPTOR expression was analyzed by the Logistic re-gression model,which showed that T stage and tumor diameter were independent influencing factors of high expression of DEPTOR.Compared with low expression group,the serum CEA level in patients with high expression group was higher,the differences was statistically significant ( P < 0.05 ). There was no significant difference in serum CA199 level between the expression group and the low expression group (P>0.05).Spearman correlation analysis showed that the expression level of DEPTOR was positively correlated with serum CEA level in rectal cancer patients (r=0.509,P<0.01).Compared with low expression group,the 5-year cumulative recurrence rate and the 5-year cumulative mortality rate in the high-expression group of DEPTOR were higher,the differences were statistically significant ( P <0.05). Conclusion DEPTOR is highly expressed and is associated with the degree of disease progression in rectal cancer,its elevation suggests a poor prognosis.关键词
DEPTOR/直肠癌/癌组织/癌旁组织/癌胚抗原/糖类抗原199Key words
DEPTOR/rectal cancer/tumor tissues/tumor-adjacent tissues/carcino-embryonic antigen/carbohydrate antigen 199分类
医药卫生引用本文复制引用
王娟,张朝阳,邵志林,闫国林,张甜甜,李燕,钟春生..DEPTOR在直肠癌中的表达及对预后的影响[J].局解手术学杂志,2018,27(10):693-698,6.
