中国临床药理学与治疗学2018，Vol.23Issue(10)：1116-1125,10.DOI:10.12092/j.issn.1009-2501.2018.10.006
多种复方中药注射液治疗小鼠化疗相关白细胞减少症
Clinical trial of multiple compound Chinese medicine injections in the treatment of mice with chemotherapy-related leukopenia
摘要
Abstract
AIM: To investigate the effects of 5 commonly-used compound traditional Chinese medi-cine ( TCM) injections and granulocyte-colony stim-ulating factor ( G-CSF) in the treatment of chemo-therapy-related leukopenia mice, as well as their effects on multiple organs and thymus of the mice. METHODS: Cyclophosphamide intraperitoneal in-jection was used to prepare mice model with Chemo-therapy-related leukopenia. The mice treated with G-CSF were taken as positive control, while the mice in each treatment group were given intraperito-neal injection of kang'ai, kushen, shenfu, shenmai and shengmai, respectively. The mice were killed the next day after drawing peripheral blood for rou-tine blood test. Cardiac blood was taken to measure serum liver and kidney function indexes ( ALT, AST, BUN and CR ) , while important organs ( heart, liver, spleen, lung, kidney) and thymus were taken to calculate the corresponding organ in-dex. RESULTS: Compared with the model group, the white blood cell ( WBC) count of the mice in the five TCM-treated groups was significantly increased ( P<0. 01 ) , which was lower than that of the G-CSF-treated group ( P<0. 05, P<0. 01) . In addi-tion, G-CSF and 5 kinds of TCM injections can pro-mote platelet at different levels ( P <0. 05, P <0. 01). Compared with the model group, the level of serum AST was slightly increased in the kushen-trea-ted group ( P=0. 036) and the shenfu-treated group ( P=0. 008) . Serum ALT and renal function index were not significantly increased in each TCM-treated group, while the spleen index decreased ( P<0. 05 or P <0. 01 ) and the lung index increased ( P <0. 01). In 5 TCM-treated groups, the liver cells of the mice showed different degrees of cellular degen-eration, spot-like necrosis and inflammatory re-sponse, but the difference between the groups was not significant. Expect for the kushen-treated group, the liver pathology score of the other TCM-treated groups was significantly lower than that of the model group ( P <0. 05, P <0. 01 ) , among which the most significant was in the shengmai-treated group (P<0. 01). CONCLUSION: All the 5 TCM in-jections can effectively treat chemotherapy-related leukopenia, which is weaker than G-CSF. Five TMC injections and G-CSF also have a certain platelet effect. In addition to kushen, the other 4 TMC in-jections may all have protective effects on liver. The effects of 5 TMC injections on other organs and thy-mus are not significant.关键词
中药注射液/粒细胞集落刺激因子(G-CSF)/化疗/白细胞减少/中性粒细胞减少Key words
TCM injections/G-CSF/chemo-therapy/leucopenia/neutropaenia分类
医药卫生引用本文复制引用
张喜平,唐镔镔,张翔,杨红健,邹德宏,乔恩奇,王准,何向明,俞星飞,章颖..多种复方中药注射液治疗小鼠化疗相关白细胞减少症[J].中国临床药理学与治疗学,2018,23(10):1116-1125,10.基金项目
浙江省中医药科技计划项目(2015ZB021) （2015ZB021）
