摘要
Abstract
AIM: To investigate the effects of fasudil combined with rosuvastatin in the treatment of vascular dementia ( VD ) on patients' cognitive function, C-reactive protein and oxidative stress. METHODS: One hundred and eighty-four VD pa-tients were selected as study subjects. They were di-vided into the rosuvastatin group and the combined drug group ( fasudil + rosuvastatin ) according to the random number table method. Each group con-tains 92 cases. MMSE ( Mini-Mental State Examina-tion) , MoCA ( Montreal Cognitive Assessment) and ADL ( Activities of Daily Living) scores, the level of CRP ( C-reactive protein ) , MDA ( malondialde-hyde), Hcy (serum homocysteine) and SOD (su-peroxide dismutase) , as well as blood lipid index ( TC, TG, LDL-C, HDL-C) levels, clinical efficacy and incidence of adverse reaction were compared be-tween the two groups before and after treatment. RESULTS:The total effective rate of the combined drug group (93. 48% ) was significantly higher than that of the rosuvastatin group (82. 61% ) , and the difference was statistically significant ( P <0. 05 ) . After treatment, the MMSE, MoCA and ADL scores of the combined drug group were significantly higher than that of the rosuvastatin group, while the level of CRP, MDA, Hcy, TC, TG and LDL-C was signifi-cantly lower than that of the rosuvastatin group, and the SOD level was significantly higher than that of the rosuvastatin group, which were of statistically significant difference ( P<0. 05) . There was no sig-nificant difference in the incidence of adverse reac-tion (P >0.05). CONCLUSION:Fasudil com-bined with rosuvastatin in the treatment of VD can improve patients'cognitive function and daily living ability, reduce oxidative stress response and the lev-el of C-reactive protein, and improve patients'blood lipid index. This method is of significant clinical ef-ficacy and high safety关键词
血管性痴呆/法舒地尔/瑞舒伐他汀/认知功能/C-反应蛋白/氧化应激Key words
vascular dementia/fasudil/rosuv-astatin/cognitive function/C-reactive protein/oxi-dative stress分类
医药卫生
