中国临床药理学杂志2018，Vol.34Issue(20)：2445-2448,4.DOI:10.13699/j.cnki.1001-6821.2018.20.015
中国近10年脂肪肝常见病因的分析
Analysis of common etiology of fatty liver in recent ten years in China
摘要
Abstract
Objective To analyze the common causes of fatty liver in Chinese adults.Methods The CNKI, WANFANG database and VIP database were searched by computer , and the etiology of fatty liver was published from January 2008 to December 2017.Meta-analysis of pre-valence, influencing factors, and blood biochemical indicators were per-formed using R software and Stata software .Results Twenty-four stu-dies were finally included,with a total of 49,275 cases.Meta-analysis showed that the prevalence of fatty liver in the population were : total prevalence 19.31%, male prevalence 26.44%, female prevalence 15.31%.The prevalence rates at different ages were :＜30 years old 13.20%, 31-40 years old 16.73%, 41-50 years old 20.98%, 51-60 years old 21.85%,＞60 years old 17.46%.The risk ratio of influen-cing factors in patients with fatty liver compared with normal population was: high cholesterol 2.03, high triglyceride 3.02, aspartate transaminas increased 3.70, alanine transaminase increased 4.55, hyperglycemia 2.54, obesity 10.73 , greasy food 3.93, alcohol consumption 2.85, hy-pertension 2.06, quality index fat 2.52.The differences in mean blood biochemical results between patients with and without fatty liver were as follows: total cholestero 1.23,triglyceride 1.18,high-density lipoprotein -0.55,low-density lipoprotein 0.28, aspartate transaminase 1.09, alanine transaminase 1.45,total bilirubin 1.09, fasting blood glucose 1.16.Conclusion The preva-lence of fatty liver in Chinese men is higher than that in females ; common factors are high cholesterol , high triglycerides, elevated aspartate transaminase, elevated alanine transaminase, hyperglycemia, obesity, greasy food, hypertension, body mass index; patients with fatty liver fatty biochemical indicators than the normal population were abnormal.关键词
脂肪肝/病因/Meta分析Key words
fatty liver/etiology/Meta-analysis分类
医药卫生引用本文复制引用
张勇勇,李三强,宋影,王善龙,朱文枫,宋晓改,买晨阳,田张钰,白飞羽..中国近10年脂肪肝常见病因的分析[J].中国临床药理学杂志,2018,34(20):2445-2448,4.基金项目
国家自然科学基金资助项目(81201558) （81201558）
河南省科技创新杰出青年课题资助项目(2018JQ0006) （2018JQ0006）
河南省高校科技创新团队资助项目(181RTSTHN026) （181RTSTHN026）
河南科技大学创新团队资助项目(2015XTD003) （2015XTD003）
河南省科技攻关课题资助项目(172102310693) （172102310693）
