中国药房2018，Vol.29Issue(20)：2845-2850,6.DOI:10.6039/j.issn.1001-0408.2018.20.24
我国成人患者抗生素相关性腹泻危险因素的Meta分析
Risk Factors for Antibiotic-associated Diarrhea in Chinese Adult Patients:A Meta-analysis
摘要
Abstract
OBJECTIVE:To evaluate the risk factors for antibiotic-associated diarrhea (AAD) in Chinese adult patients systematically,and to provide evidence-based reference in clinic. METHODS:Retrieved from CNKI,VIP,CBM,Wanfang database,PubMed and Embase,etc.,disease control studies about AAD risk factors of Chinese adult patients were collected.The retrieval time limit ranged from Jan. 2000 to Jan. 2018. Meta-analysis was performed by using Rev Man 5.2 software after data extraction and quality evaluation of included literatures with NOS scale. RESULTS:A total of 14 literatures were included, involving 20 914 patients. The result of Meta-analysis showed that age ≥65 years [OR＝2.36,95%CI(1.99,2.79),P＜0.001], fasting [OR＝4.65,95%CI(3.79,5.69),P＜0.001],use of acid suppressant [OR＝5.82,95%CI(3.77,8.98),P＜0.001],serum albumin ≤30 g/L [OR＝2.40,95%CI(2.00,2.88),P＜0.001],invasive operation [OR＝3.95,95%CI(3.03,5.15),P＜0.001], stay in ICU [OR＝2.93,95%CI(2.38,3.60),P＜0.001],hospitalization time ≥10 d [OR＝4.08,95%CI(3.31,5.03),P＜0.001], antibiotic species ≥3 kinds [OR＝1.98,95%CI(1.56,2.51),P＜0.001] and duration of antibiotics use ≥10 d [OR＝6.16,95%CI (3.22,11.76),P＜0.001] were significantly correlated with the occurrence of AAD. CONCLUSIONS:Age ≥65 years,fasting, use of acid suppressant,serum albumin ≤30 g/L,invasive operation,stay in ICU,time of hospitalization ≥10 d,antibiotic species≥3 kinds and duration of antibiotics use≥10 d are risk factors for AAD in Chinese adult patients.关键词
抗生素相关性腹泻/成人患者/危险因素/Meta分析Key words
Antibiotic-associated diarrhea/Adult patients/Risk factor/Meta-analysis分类
医药卫生引用本文复制引用
毛婷,李吉莹,王胜红,钟建明,李晓兰..我国成人患者抗生素相关性腹泻危险因素的Meta分析[J].中国药房,2018,29(20):2845-2850,6.基金项目
湖北省科技计划项目(No.2015CFB574) （No.2015CFB574）
