中国药房2018，Vol.29Issue(20)：2851-2855,5.DOI:10.6039/j.issn.1001-0408.2018.20.25
消渴方治疗气阴两虚型2型糖尿病疗效的Meta分析
Therapeutic Efficacy of Xiaoke Formula in the Treatment of Type 2 Diabetes Mellitus with Qi and Yin Deficiency:A Meta-analysis
摘要
Abstract
OBJECTIVE:To systematically evaluate therapeutic efficacy of Xiaoke formula in the treatment of type 2 diabetes mellitus (T2DM) with Qi and Yin deficiency,and to provide evidence-based reference in clinic. METHODS:Retrieved from PubMed,Embase,Cochrane Library,CBM and CNKI,randomized controlled trials(RCTs)about modified Xiaoke formula(trial group) with Qi and Yin deficiency versus Metformin tablet or insulin(control group) in the treatment of T2DM were included. After literature screening and data extraction,the qualities of included studies were evaluated by modified Jadad scoring scale. Meta-analysis was performed by using Rev Man 5.3 statistical software. RESULTS:Totally 18 RCTs were included,involving 2 065 patients. Meta-analysis showed that response rate of trial group [OR＝2.89,95%CI(2.16,3.86),P＜0.001] was significantly higher than that of control group,while fasting blood glucose [SMD＝－0.72,95%CI(－0.96,－0.47),P＜0.001],2 h postprandial blood glucose [SMD＝ －0.72,95%CI(－0.96,－0.47),P＜0.001],glycosylated hemoglobin [MD＝－0.65,95%CI (－0.88,－0.42),P＜0.001] and TCM syndrome score [MD＝－5.77,95%CI(－7.46,－4.08),P＜0.001] were significantly lower than control group. Totally 18 RCTs were included,involving 18 formula and 66 ingredients. The sum of use frequency of various medicinal materials was 218. Trichosanthes,Coptis chinensis,Ophiopogon japonicus and so on were used most frequently. CONCLUSIONS:Xiaoke formula shows significant therapeutic efficacy for T2DM with Qi and Yin deficiency,and reduces related index levels and TCM syndrome score effectively.关键词
消渴方/气阴两虚型/2型糖尿病/疗效/Meta分析Key words
Xiaoke formula/Qi and Yin deficiency/Type 2 diabetes mellitus/Therapeutic efficacy/Meta-analysis分类
医药卫生引用本文复制引用
张蔚,雷鸣..消渴方治疗气阴两虚型2型糖尿病疗效的Meta分析[J].中国药房,2018,29(20):2851-2855,5.基金项目
宁夏青年科技人才托举工程项目 （）
