中国医学创新2018，Vol.15Issue(28)：1-4,4.DOI:10.3969/j.issn.1674-4985.2018.28.001
外周血和尿锌浓度对儿童细菌性重症肺炎病情评估的临床研究
Detection of Peripheral Blood and Urine Zinc Levels in Children with Severe Bacterial Pneumonia
摘要
Abstract
Objective:To explore the clinical value of detection of peripheral blood and urine Zinc levels in children with severe bacterial pneumonia.Method:104 children with severe pneumonia diagnosed and cured in our hospital from January 2013 to December 2015 were selected as observation group and 122 children with mild pneumonia were selected as control group.The serum Zinc and urine Zinc concentration were detected before, during and after treatment.The serum and urine Zinc concentrations of two groups were compared,the improvement of clinical performance when blood and urine Zinc concentration changed of two groups were compared,and the diagnostic value of serum and urine Zinc was analyzed.Result:During treatment,the serum Zinc concentration in observation group was lower than that of control group(P<0.05),the fever subsided and cough improved in two groups were compared,the differences were statistically significant(P<0.05),but wheezing relief and eating increase in two groups were compared,the differences were not statistically significant(P>0.05).After treatment, the urine Zinc concentration in observation group was lower than that of control group(P<0.05),the fever subsided,cough improved,wheezing relief and eating increase in two groups were compared,the differences were not statistically significant(P>0.05).The area under the ROC curve of serum Zinc was 0.90,which was higher than 0.58 of urine Zinc(P<0.05),the sensitivity of serum Zinc was 88.9%,which was higher than 42.2% of urine Zinc(P<0.05),the specificity of serum Zinc was 48.7%,which was higher than 45.7% of urine Zinc,but the difference was not statistically significant(P>0.05).Conclusion:Detection of serum and urine Zinc concentration can effectively evaluate the course of severe bacterial pneumonia in children,and the sensitivity of serum Zinc for severe bacterial pneumonia is better than that of urine Zinc determination.It can be used as an effective index for evaluating the condition of severe bacterial pneumonia in children.关键词
锌/重症肺炎/儿童Key words
Zinc/Severe pneumonia/Children引用本文复制引用
谭艳芳,邓文,郭素华,谢梅,赵慧,周真,李增清..外周血和尿锌浓度对儿童细菌性重症肺炎病情评估的临床研究[J].中国医学创新,2018,15(28):1-4,4.基金项目
广东省医学科研基金(B2015054) （B2015054）
