中国医学创新2018，Vol.15Issue(28)：22-25,4.DOI:10.3969/j.issn.1674-4985.2018.28.006
康莱特联合重组人白介素-2灌注治疗恶性胸腔积液临床观察
Clinical Observation of Kanglaite Injection Combined with Recombinant Human Interleukin-2 in the Treatment of Malignant Pleural Effusion
摘要
Abstract
Objective:The natural anti-cancer active substances of Kanglaite Injection were widely concerned by the clinic.The purpose of this study was to observe the effect of Kanglaite Injection combined with Recombinant Human Interleukin-2 perfusion in the treatment of malignant pleural effusion and the improvement of patients'quality of life.Method:A total of 80 patients with advanced lung cancer complicated with pleural effusion admitted in our hospital from June 2016 to December 2017 were selected as the study objects.According to the random number table method, They were divided into observation group and control group,40 cases in each group. The observation group was given Recombinant Human Interleukin-2 plus Kanglaite Injection pleural perfusion treatment,the control group was only given Recombinant Human Interleukin-2 pleural perfusion treatment.After treatment 4 weeks,the efficacy,quality of life and toxic and side effects between the two groups were compared. Result:After treatment 4 weeks,the total effective rate in the observation group was 87.5%,the complete remission,partial remission and stable disease+disease progression were 13 cases (32.5%),22 cases (55.0%) and 5 cases (12.5%) respectively.The total effective rate in the control group was 67.5%,9 cases (22.5%),18 cases (45.0%) and 13 cases (32.5%) had complete remission,partial remission and stable disease+disease progression respectively.The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant ( x2=4.587 8,P=0.032 2).The improvement of KPS score in the observation group was significantly better than that in the control group,the difference was statistically significant (P<0.05). There was no significant difference in the incidence of toxic and side effects between the two groups (P>0.05).Conclusion:Kanglaite Injection combined with Recombinant Human Interleukin-2 can significantly improve the efficacy of lung cancer with malignant pleural effusion,has small toxic and side effects and significantly improve the quality of life of patients,which is worthy of clinical promotion.关键词
康莱特/重组人白介素-2/胸腔积液/生活质量Key words
Kanglaite Injection/Recombinant Human Interleukin-2/Pleural effusion/Quality of life引用本文复制引用
王小毛,郭守俊,曾春生..康莱特联合重组人白介素-2灌注治疗恶性胸腔积液临床观察[J].中国医学创新,2018,15(28):22-25,4.基金项目
江西省卫生计生委科技计划项目(20167232) （20167232）
