中国医学创新2018，Vol.15Issue(29)：26-29,4.DOI:10.3969/j.issn.1674-4985.2018.29.007
IVC独立送风系统在裸鼠繁育中的应用及其效果分析
Application and Effect Analysis of IVC Independent Air Supply System in Nude Mice Breeding
摘要
Abstract
Objective:To explore the application and effect of IVC independent air supply system in nude mice breeding.Method:In June 2016,a room of about 20 m2was selected from the laboratory animal center of our hospital,on the basis of specific pathogen free(SPF) barrier system,the IVC independent air supply system was installed as the study group;the room of the same size was selected and the SPF barrier system was installed only as the control group.At the beginning of the study,6 female rats (nu/+) and 6 male rats (nu/nu) were placed in the control group and the study group,and the cage was placed according to the ratio of male to female ratio (1︰1).As of December 2017,the delivery interval,average number of litter per litter and survival rate of the two groups were calculated.Result:There were no significant differences between the two groups in the delivery interval and the average litter size per litter(P>0.05).The survival rate of the study group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:The application of IVC independent air supply system in the breeding process of nude mice can significantly improve the survival rate of nude mice,which can provide many high quality experimental animals for clinical animal experiments.关键词
裸鼠/SPF屏障系统/IVC独立送风系统/分娩间隔/存活率Key words
Nude mice/SPF barrier system/IVC independent air supply system/Delivery interval/Survival rate引用本文复制引用
刘勇,赵龙,张凡,柏合..IVC独立送风系统在裸鼠繁育中的应用及其效果分析[J].中国医学创新,2018,15(29):26-29,4.基金项目
牡丹江市科学技术计划项目(Z2016s0092) （Z2016s0092）
