中国医学创新2018，Vol.15Issue(30)：17-21,5.DOI:10.3969/j.issn.1674-4985.2018.30.005
醒脑静联合阿托伐他汀钙治疗慢性硬膜下血肿患者的临床疗效
Clinical Efficacy of Xingnaojing Combined with Atorvastatin Calcium in the Treatment of Chronic Subdural Hematoma
摘要
Abstract
Objective:To observe the clinical effect of Xingnaojing combined with Atorvastatin Calcium on postoperative elderly patients with chronic subdural hematoma(CSDH).Method:A total of 66 elderly CSDH patients who underwent drilling drainage in our hospital from July 2016 to December 2017 were selected.According to the random number table method,they were divided into combined group(given Xingnaojing+Atorvastatin Calcium treatment),Xingnaojing group(Xingnaojing treatment),Atorvastatin Calcium group(Atorvastatin Calcium treatment),22 cases in each group.The intracranial nerve function(NIHSS score) and the amount of intracranial hemorrhage were compared before and after administration7,14 and 30 days,and serum inflammatory factors(TNF-α,hs-CRP) before and after administration in three groups were compared. Restult:During the administration period,the NIHSS scores of three groups were lower than those of before administration,and the NIHSS scores of combined group were lower than those of Xingnaojing group and Atorvastatin Calcium group,the differences were statistically significant(P<0.05),and administration 30 d,the NIHSS scores of Atorvastatin Calcium group was lower than that of Xingnaojing group(P<0.05).Administration 7 and 14 d,the amount of intracranial hemorrhage in three groups was significantly lower than those of before treatment(P<0.05),but the three groups were compared,the differences were not statistically significant (P>0.05),administration 30 d,the amount of intracranial hemorrhage in combined group were lower than those of the other two groups and before administration(P<0.05),but the amount of intracranial hemorrhage in Xingnaojing group and Atorvastatin Calcium group was compared,the difference was not statistically significant (P>0.05).After administration,the TNF-α and hs-CRP levels in three groups were lower than those of before administration,and the combined group were lower than those of Xingnaojing group and Atorvastatin Calcium group,the differences were statistically significant(P<0.05),but the levels of TNF-α and hs-CRP in Xingnaojing group and Atorvastatin Calcium group were compared,the differences were not statistically significant(P>0.05). Conclusion:For elderly patients with CSDH after drilling drainage,Xingnaojing combined with Atorvastatin Calcium treatment can significantly improve the neurological deficit score,promote the absorption of hematoma and significantly reduce the inflammatory factors in the body,which is worthy of promotion and application.关键词
慢性硬膜下血肿/老年人/钻孔外引流术/醒脑静/阿托伐他汀钙Key words
Chronic subdural hematoma/Elderly/Drilling drainage/Xingnaojing/Atorvastatin calcium引用本文复制引用
江庆炎,邱兵,肖刘福,梁仔..醒脑静联合阿托伐他汀钙治疗慢性硬膜下血肿患者的临床疗效[J].中国医学创新,2018,15(30):17-21,5.基金项目
2015年度湛江市科技专项备用经费项目(2015C01012) （2015C01012）
