中国医学创新2018，Vol.15Issue(30)：21-24,4.DOI:10.3969/j.issn.1674-4985.2018.30.006
经皮冠状动脉介入治疗术后标准双抗血小板治疗和长期双抗血小板治疗的预后对比
Effect of Standard Double Antiplatelet and Long Term Dual Antiplatelet Therapy on Prognosis of Patients with Coronary Heart Disease after Percutaneous Coronary Intervention
摘要
Abstract
Objective:To discuss the effect of standard double antiplatelet and long term dual antiplatelet therapy on prognosis of patients with coronary heart disease after percutaneous coronary intervention(PCI). Method:The clinical data of 200 patients with coronary artery disease who returned to our hospital after PCI from January 2015 to December 2017 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,100 cases in each group.The observation group received long term dual antiplatelet therapy,while control group received standard double antiplatelet therapy.The platelet aggregation rate,erythrocyte count and platelet count before and after treatment,effective endpoint events and safety endpoint events between two groups were compared.Result:Before treatment and 3,6 and 12 months after treatment, the platelet aggregation rate,erythrocyte count and platelet count in two groups were compared,the differences were not statistically significant(P>0.05).18 and 24 months after treatment,the erythrocyte count in two groups were compared,the differences were not statistically significant(P>0.05),but the platelet aggregation rate and platelet count in observation group were lower than those of control group,the differences were statistically significant(P<0.05).The incidence of major and minor end point events in observation group were lower than those of control group,the differences were statistically significant(P<0.05).The incidence of major bleeding,small bleeding and total incidence of safety endpoints in two groups were compared,the differences were not statistically significant(P>0.05).Conclusion:Long term dual antiplatelet therapy after PCI can safely and effectively inhibit platelet aggregation,reduce the incidence of postoperative cardiovascular adverse events in patients with coronary heart disease.关键词
经皮冠状动脉介入治疗术/冠心病/氯吡格雷/阿司匹林Key words
Percutaneous coronary intervention/Coronary heart disease/Clopidogrel/Aspirin引用本文复制引用
陈罗文,杜淑连,杨学成,林森..经皮冠状动脉介入治疗术后标准双抗血小板治疗和长期双抗血小板治疗的预后对比[J].中国医学创新,2018,15(30):21-24,4.基金项目
佛山市卫生和计生局医学科研课题(20170342) （20170342）
