中国医学创新2018，Vol.15Issue(30)：33-36,4.DOI:10.3969/j.issn.1674-4985.2018.30.009
绝经后骨质疏松患者维生素D与基质Gla蛋白的相关性研究
Correlation between Vitamin D and Matrix Gla Protein in Patients with Postmenopausal Osteoporosis
摘要
Abstract
Objective:To observe the correlation of serum 25-hydroxyvitamin D3level and serum matrix Gla protein (MGP) in patients with postmenopausal osteoporosis.Method:A total of 125 postmenopausal women who underwent outpatient physical examination in the Second Affiliated Hospital of Nanchang University from April 2013 to February 2016 were selected as study objects.Bone mineral density (BMD),serum 25-hydroxyvitamin D3 and serum MGP levels of all patients were measured. According to the results of bone mineral density,they were divided into normal bone density group (30 cases),low bone mass group (47 cases) and osteoporosis group (48 cases).According to serum 25-hydroxyvitamin D3concentration,the patients with low bone mass and osteoporosis were divided into deficiency group (34 cases),insufficiency group (31 cases) and normal group (30 cases).The serum levels of MGP in each group were observed and their correlation with BMD and serum 25-hydroxyvitamin D3were analyzed.Result:The levels of serum MGP in the normal BMD group were significantly higher than those in the low BMD group and osteoporosis group,the differences were statistically significant (P<0.05).The serum levels of 25-hydroxyvitamin D3in the normal group were significantly higher than those in the insufficiency group and deficiency group,the differences were statistically significant (P<0.05).Correlation analysis showed that serum MGP concentration was positively correlated with bone mineral density and 25-hydroxyvitamin D3 concentration.Conclusion:Serum MGP of patients with postmenopausal osteoporosis is closely associated with serum 25-hydroxyvitamin D3and BMD.Along with the gradual decline of serum 25-hydroxyvitamin D3level,the extent of serum MGP gradually decrease.关键词
维生素D/绝经后骨质疏松/基质Gla蛋白Key words
Vitamin D/Postmenopausal osteoporosis/Matrix Gla protein引用本文复制引用
谢菲飞,谢宝强,杨雅..绝经后骨质疏松患者维生素D与基质Gla蛋白的相关性研究[J].中国医学创新,2018,15(30):33-36,4.基金项目
江西省自然科学基金(20142BAB205016) （20142BAB205016）
