安徽大学学报（自然科学版）2018，Vol.42Issue(5)：99-104,6.DOI:10.3969/j.issn.1000-2162.2018.05.011
基于肿瘤蛋白-蛋白相互作用网络的药物靶标发现
The OncoPPi network: cancer-associated protein-protein interaction networks for therapeutic target discovery
傅海安1
作者信息
- 1. 埃默里大学医学院药理学系,美国佐治亚州亚特兰大30322
- 折叠
摘要
Abstract
As genomics advances reveal the cancer gene landscape,a daunting task is to translate these enormous volumes of information into efficacious genomics-based treatments for cancer patients.To address this challenge,the NCI Cancer Target Discovery and Development (CTD2) Network was created in the US.As a member of the CTD2 Network,the Emory CTD2 Center focuses specifically on the functional dimension of the cancer genome to establish re-wired protein-protein interaction (PPI) networks in cancer for therapeutic target discovery.To achieve this goal,high throughput screening technologies were utilized along with high throughput informatics approach.We aim to rapidly map molecular interactions among cancer associated proteins,leading to the generation of a cancer-associated PPI (OncoPPi) network.OncoPPi is a focused PPI resource that links cancer genes into a signaling network for discovery of PPI targets and network-implicated tumor vulnerabilities.This resource is accessible from the Emory OncoPPi portal.Emory's approach is an integral component of the CTD2 network,which allows timely data sharing and close collaboration.Together,we aim to develop the next generation of pathway-perturbation agents to selectively disrupt re-wired oncogenic signaling networks for genomics-directed precision medicine.关键词
基因组学/癌症/蛋白-蛋白相互作用/靶标/网络Key words
genomics/cancer/protein-protein interaction/target/network分类
生物科学引用本文复制引用
傅海安..基于肿瘤蛋白-蛋白相互作用网络的药物靶标发现[J].安徽大学学报（自然科学版）,2018,42(5):99-104,6.
