国际医药卫生导报2018，Vol.24Issue(22)：3377-3380,4.DOI:10.3760/cma.j.issn.1007-1245.2018.22.004
血清同型半胱氨酸水平对2型糖尿病患者视网膜及肾脏病变的影响
Effect of plasma homocysteine level on retinopathy and kidney disease in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the relationships between plasma homocysteine (Hcy) on one hand and type 2 diabetic retinopathy and renal disease on the other hand.Methods From January,2017 to May,2018,150 patients with type 2 diabetes were treated in our hospital,including 64 patients with simple type 2 diabetes (DM group),35 diabetic retinopathy (DR group),31 diabetic nephropathy (DN group),and 20 diabetic retinopathy and nephrotic patients (DR+DN group).50 volunteers were set as a control group.The levels of Hcy,fasting blood glucose (FBG),insulin resistance index (HOMA-IR),and so on were detected.Results The FBG in the DM group,the DR group,the DN group,and the DR+DN group were (8.91±0.99) mmol/L,(9.02±1.03) mmol/L,(9.00±1.03) mmol/L,and (8.98±0.97) mmol/L,respectively,with no statistical differences (P ＞ 0.05).The Hcy,glycosylated hemoglobin (HbAlc),vascular endothelial growth factor (VEGF),HOMA-IR,and urinary albumin excretion rate (UAE) were obviously higher in the DR+DN group than in the DN group,the DR group,the DM group,and the control group (P ＜ 0.05).The Hcy and HbAlc in the patients with proliferative retinopathy (PDR) were (16.55±2.15) mmol/L and (9.01±0.98)％,which were significantly higher than those in the patients with non-proliferative retinopathy (NPDR) [(13.49±3.03) mmogL and (8.00±1.20)％],P ＜ 0.05.The Hcy positively correlated with FBG,HbAlc,VEGF,HOMA-IR,and UAE (r=0.341,0.322,0.415,0.352,and 0.481,all P ＜ 0.05).Conclusions Plasma Hcy level correlates with retinopathy and kidney disease in type 2 diabetic patients,and may be a valuable biological marker.关键词
同型半胱氨酸/2型糖尿病/糖尿病视网膜病变/糖尿病肾病Key words
Homocysteine/Type 2 diabetes mellitus/Diabetic retinopathy/Diabetic nephropathy引用本文复制引用
宋丽,任传涛,刘晓钰,赵青,岳杉..血清同型半胱氨酸水平对2型糖尿病患者视网膜及肾脏病变的影响[J].国际医药卫生导报,2018,24(22):3377-3380,4.基金项目
Project of Developmental Plan of Medical Science and Technology in Shandong (2017WS827)山东省医药卫生科技发展计划项目(2017WS827) （2017WS827）
