神经损伤与功能重建2018，Vol.13Issue(11)：555-557,571,4.DOI:10.16780/j.cnki.sjssgncj.2018.11.005
儿童复发髓母细胞瘤综合治疗及疗效分析
Comprehensive Treatment and Analysis of Medulloblastoma in Children
彭其斌 1赵建农 1王鹏程 1陈宝智 1刘颖2
作者信息
- 1. 海南省人民医院神经外科 海口 570311
- 2. 武汉大学医学研究院 武汉 430071
- 折叠
摘要
Abstract
Objective: To analyze the comprehensive therapy and treatment results of medulloblastoma (MB) in children. Methods: A total of 57 patients diagnosed with medulloblastoma from January 2014 to August 2017 were enrolled in this retrospective analysis among which 51 children had total resection and 6 children partial resection during initial treatment. Following surgery, patients accepted three-dimensional radiotherapy (3DCRT) and intensity-modulated radiation therapy (IMRT). During postoperative radiotherapy, patients underwent concurrent chemoradiotherapy or radiotherapy alone after which patients were treated with 5 courses of chemotherapy. The median follow-up period was 15 months. Results: Of all patients, the median survival length was 29.12 months. The 6-month, 1-, 2-, and 3-year overall survival rate was 91.23% , 73.68% , 54.38% , and 40.35%, respectively. Univariate analysis showed that the overall survival rate of children with medulloblastoma was affected by the range of surgical resection (P=0.005), tumor size (P=0.048), and concurrent chemotherapy during postoperative radiotherapy (P=0.002). Multivariate analysis showed that the greater the tumor size, the worse the prognosis (P=0.041) and that simultaneous chemotherapy during postoperative radiotherapy could improve prognosis (P=0.002). Conclusion: Medulloblastoma in children is predominantly a high-grade tumor with poor prognosis and can cause considerable damage to the children’s nervous system. The treatment program should consist of comprehensive therapy combining surgical resection with chemotherapy and radiotherapy and also chemotherapy during postoperative radiotherapy to improve patient survival rate.关键词
髓母细胞瘤/综合治疗/儿童/神经外科/预后Key words
medulloblastoma/comprehensive treatment/children/neurosurgery/prognosis分类
医药卫生引用本文复制引用
彭其斌,赵建农,王鹏程,陈宝智,刘颖..儿童复发髓母细胞瘤综合治疗及疗效分析[J].神经损伤与功能重建,2018,13(11):555-557,571,4.
