摘要
Abstract
Objective To observe the clinical effect of penehyclidine hydrochloride in the treatment of septic shock. Methods 64 cases of subjects conformed to the inclusion criteria in intensive care unit (ICU) of our hospital from 2013 to 2015 were selected, and were divided into group A (control group), group B (654-2 group), and group C (penehyclidine hydrochloride group) according to the random number table method. Then, the heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation (SPO2), urine volume, and central venous pressure (CVP) were recorded before treatment and1 hour, 6 hours, 24 hours, and 48 hours after treatment, the blood gas analysis (lactic acid) was measured, and the hospitalization time and the mortality were counted and were compared. Results The improvement effect of MAP, CVP, SPO2, and lactic acid in the group C were significantly better than those in the group A and group B, and the hospitalization time was shortened [(12.8±1.5) d, (15.7±3.1)d, (14.6±2.7)d], with statistically significant differences (P<0.05); the mortality within 28 days after onset in the group C was the lowest (19.05％ vs. 40.91％ vs. 33.33％), but without statistically significant difference among the three groups (P>0.05), which did not increase the heart rate of patients. Conclusion The clinical effect of penehyclidine hydrochloride in the treatment of septic shock is much better, without side effects of heart rate increase, worthy to be promoted and applied in the clinical.关键词
感染性休克/盐酸戊乙奎醚/654-2(东莨菪碱)Key words
Septic shock/Penehyclidine hydrochloride/654-2 (scopolamine)
