摘要
Abstract
Objective To explore and analyze the effect of low molecular heparin in the treatment of pre-eclampsia complicated with fetal growth restriction and the effects on growth and development. Methods 90 cases of pre-eclampsia complicated with fetal growth restriction treated at our hospital from April, 2015 to April, 2017 were selected, and randomly divided into a control group and an observation group, 45 cases for each group. The control group were treated with magnesium sulfate; in addition, the observation group were treated with low molecular heparin. The clinical curative effect, fetal growth situation and umbilical cord blood flow indicators before and 1 week after the treatment, neonatal Apgar score, body weight, placenta quality, and ho-1expression level were compared between these two groups. Results The total clinical efficacy was higher in the observation group than in the control group (91.11％ vs. 73.33％), with a statistical difference (P < 0.05). There were no statistical differences in biparietal diameter, femur length, abdomen circumference, head circumference, S/D ratio, PT, and RI between these two groups before the treatment, and no between before and after the treatment in the control group(P > 0.05). The biparietal diameter, femur length, abdomen circumference, and head circumference were higher and the S/D ratio, PT, and RI were lower after than before the treatment in the observation group, with statistical differences (all P < 0.05). The neonatal Apgar score, body weight, and placenta quality were higher in the observation group than in the control group, with statistical differences (all P < 0.05). The proportions of strong and moderate positive expressions of HO-1 were higher in the observation group than in the control group, with statistical differences (both P < 0.05). Conclusion Low molecular heparin combining magnesium sulfate is effective in the treatment of pre-eclampsia complicated with fetal growth restriction, and can further promote growth and development.关键词
低分子肝素/子痫前期/胎儿生长受限/疗效/生长发育Key words
Low molecular heparin/Preeclampsia/Fetal growth restriction/Curative effect/Growth and development
