摘要
Abstract
Objectives To observe the clinical efficacy of compound glycyrrhizin injection combined with ademetionine in the treatment of infantile cytomegalovirus (CMV) hepatitis. Methods A total of 68 infants with cytomegalovirus hepatitis who met the inclusion criteria and were treated at our hospital from January, 2017 to January, 2018 were randomly divided into a control group and a study group, 34 cases for each group. The control group were treated with ganciclovir, and the study group with ganciclovir, compound glycyrrhizin injection, and ademetionine. The 2 groups were treated for 14 days. The liver and spleen size, serum total bilirubin(STB), alanine aminotransferase(ALT), and aspartate aminotransferase(AST), serum CMV-IgM antibody, and CMV-DNA positive rate were observed and recorded before and after the treatment. Results The total effective rate was 97.1％ (33/34) in the study group, and 82.4％ (28/34) in the control group, with a statistical difference ( P < 0.05). After the treatment, the liver size and the spleen size decreased more in the study group than in the control group [(2.02±0.25) cm vs. (1.09±0.34) cm and (1.34±0.23) cm vs. (0.75±0.33) cm, both P < 0.05]. The levels of STB, ALT, and AST were lower after than before the treatment in both groups, with statistical differences (all P < 0.05). After the treatment, the levels of STB, ALT, and AST and the positive rates of CMV-IgM and CMV-DNA were significantly lower in the study group than in the control group [(67.5±34.8)U/L vs. (125.3±41.6)U/L, (73.9±22.7) U/L vs. (135.7±25.8)U/L, (45.1±21.6)mmol/L vs. (96.8±30.8)mmol/L, 14.7％ vs. 67.6％, and 17.6％vs. 64.7％], with statistical differences (all P < 0.05). There was no statistical difference in the incidence of clinical adverse reactions between the 2 groups (P > 0.05). Conclusions Compound glycyrrhizin injection combined with ademetionine for infantile cytomegalovirus hepatitis can significantly reduce their symptoms of hepatosplenomegaly, levels of STB, ALT, and AST, and positive rates of blood CMV-IgM antibody and CMV-DNA, and improve the treatment efficacy.关键词
婴儿/肝炎/巨细胞病毒/腺苷蛋氨酸/复方甘草酸苷注射液Key words
Infants/Hepatitis/Cytomegalovirus/Ademetionine/Compound glycyrrhizin injection
