中国卒中杂志2018，Vol.13Issue(12)：1243-1250,8.DOI:10.3969/j.issn.1673-5765.2018.12.003
后循环CTA评分对急性基底动脉闭塞机械取栓临床结局的预测作用研究
The Predictive Value of Posterior Circulation Computed Tomography Angiography Score in Outcome of Mechanical Thrombectomy for Acute Basilar Artery Occlusion
杨海华 1马宁 2刘恋 2莫大鹏 2高峰 2缪中荣2
作者信息
- 1. 102600 北京首都医科大学北京大兴区人民医院神经内科
- 2. 首都医科大学附属北京天坛医院神经介入中心
- 折叠
摘要
Abstract
Objective To assess and validate the value of posterior circulation computed tomography angiography (pc-CTA) score in predicting the clinical outcome of mechanical thrombectomy in patients with acute basilar artery occlusion (BAO) using cerebral digital subtraction angiography (DSA). Methods The clinical and angiographic data of 86 consecutive patients with acute BAO were retrospectively analyzed. The pc-CTA score was used to assess thrombus burden. Successful recanalization was defined as thrombolysis in cerebral infarction (TICI) score 2b/3. Favorable outcome was defined as a modified Rankin scale (mRS) score of 0-2 at 3 months. Receiver operating characteristic (ROC) curve was used to determine the area under the curve (AUC) and the optimal cutoff value. Multivariate logistic regression analysis was used to identify the independent predictor of clinical outcome at 3 months. Results A total of 86 acute BAO patients who had undergone mechanical thrombectomy were identified: 78 (90.7%) achieved successful recanalization (TICI 2b/3) and 30 (34.9%) had a favorable outcome (mRS 0-2). The univariate analysis showed that there was significant difference in the pc- CTA score between favorable outcome and poor outcome groups (P=0.005). ROC analysis indicated that the AUC of the pc-CTA score was 0.681 [95% confidence interval (CI) 0.572-0.778], and the optimal cutoff value was 2 (sensitivity: 53.33%, specificity: 80.36%). The multivariate logistic regression analysis showed that the pc-CTA score ≤2 could independently predict the 3-month favorable outcome in acute BAO patients treated with mechanical thrombectomy (odds ratio 3.831;95% CI 1.302-11.273, P=0.015). Conclusions The pc-CTA score may independently predict the short clinical outcome in acute BAO patients treated with thrombectomy.关键词
基底动脉闭塞/机械取栓/后循环计算机断层扫描血管成像评分/临床结局Key words
Basilar artery occlusion/ Mechanical thrombectomy/ pc-CTA score/ Clinical outcome引用本文复制引用
杨海华,马宁,刘恋,莫大鹏,高峰,缪中荣..后循环CTA评分对急性基底动脉闭塞机械取栓临床结局的预测作用研究[J].中国卒中杂志,2018,13(12):1243-1250,8.
