国际医药卫生导报2019，Vol.25Issue(1)：66-68,3.DOI:10.3760/cma.j.issn.1007-1245.2019.01.019
急性缺血性卒中患者阿替普酶静脉溶栓后发生早期神经功能恶化的危险因素分析
Risk factors of early neurological deterioration after intravenous thrombolysis by alteplase for patients with acute ischemic stroke
秦保健 1李琳2
作者信息
- 1. 山东省单县中心医院神经内科 274300
- 2. 山东省单县中心医院心电检查科 274300
- 折叠
摘要
Abstract
Objective To investigate the risk factors of early neurological deterioration after intravenous thrombolysis by alteplase for patients with acute ischemic stroke.Methods A total of 224 patients with acute ischemic stroke treated with intravenous thrombolysis by alteplase and enrolled in our hospital from July,2016 to August,2018 were selected and divided into a progression group (n=37) and a non-progression group (n=187) according to whether or not complicated with early neurological deterioration.The risk factors of early neurological deterioration were analyzed by single factor and multivariate logistic regression analysis,and by univariate and multivariate Logistic regression analysis.Results Multivariate logistic regression analysis showed that age,diabetes,NIHSS score,white blood cell count,dysphagia,coma,and cardiogenic cerebral infarction were independent risk factors for early neurological deterioration.Conclusions There are many risk factors for early neurological deterioration after thrombolytic therapy.The related examinations should be strengthened before thrombolysis and the patients' conditions should be closely observed during the treatment so as to relieve the disease progression.关键词
急性缺血性卒中/静脉溶栓/阿替普酶/早期神经功能恶化Key words
Acute ischemic stroke/Intravenous thrombolysis/Alteplase/Early neurological deterioration引用本文复制引用
秦保健,李琳..急性缺血性卒中患者阿替普酶静脉溶栓后发生早期神经功能恶化的危险因素分析[J].国际医药卫生导报,2019,25(1):66-68,3.
