国际医药卫生导报2019，Vol.25Issue(2)：225-227,3.DOI:10.3760/cma.j.issn.1007-1245.2019.02.017
BCR-ABL融合基因与慢性粒细胞白血病的相关性分析
Correlation analysis between BCR-ABL fusion gene and chronic myeloid leukemia
王金1
作者信息
- 1. 郑州大学附属儿童医院河南省儿童遗传代谢性疾病重点实验室郑州儿童医院 450018
- 折叠
摘要
Abstract
Objective To explore the value of BCR-ABL fusion gene in the diagnosis of chronic myeloid leukemia (CML) and clinical staging.Methods The clinical data of 59 children with CML admitted to our hospital in recent years were analyzed retrospectively.The mutation rates of BCR-ABL fusion gene and BCR-ABL mutation rates in different stages were compared between CML and healthy children.Results The mutation rate of BCR-ABL in the observation group was 89.8％,while that in the control group was negative (P＜0.01);the mutation rates of BCR-ABL in chronic phase,remission phase,acceleration phase,and acute phase were 96.8％,25.0％,85.7％,and 100.0％ respectively.Conclusion BCR-ABL fusion gene can be used as an important marker for the diagnosis and staging of CML,and has positive value for clinical diagnosis and treatment according to clinical staging.关键词
BCR-ABL融合基因/慢性粒细胞白血病/诊断/分期Key words
BCR-ABL fusion gene/Chronic myeloid leukemia/Diagnosis/Staging引用本文复制引用
王金..BCR-ABL融合基因与慢性粒细胞白血病的相关性分析[J].国际医药卫生导报,2019,25(2):225-227,3.
