动物营养学报2019，Vol.31Issue(2)：544-552,9.DOI:10.3969/j.issn.1006-267x.2019.02.008
谷氨酸吸收转运及对肠道发育影响的研究进展
Research Progress of Glutamate Absorption and Transport and Its Effects on Intestinal Development
摘要
Abstract
As the main energy substrate of intestinal epithelium, glutamate provides energy for normal physio-logical function of intestinal mucosa, including nutrients absorption and transport, signal conduction, as well as the self-renewal and the maintenance of the highly ordered structure of mucosal epithelial cells. Meanwhile, as an important signaling molecular and functional amino acid, it can activate the mammalian target of rapamycin complex 1 ( mTORC1) signaling pathway, participate in protein synthesis, induce cell proliferation, enhance intestinal antioxidant ability, and then protect the integrity and function of intestinal epithelium, promote intesti-nal development. In this paper, we reviewed the research progress of glutamate absorption and transport, meta-bolic system, and its effect on the mTORC1 signaling pathway and intestinal barrier function, in order to pro-vide useful information for the exploitation of glutamate function and the application of regulation of intestinal development in production practice.[ Chinese Journal of Animal Nutrition, 2019, 31(2) :544-552]关键词
谷氨酸/肠道/吸收转运/屏障功能/调控Key words
glutamate/intestine/absorption and transport/barrier function/regulation分类
农业科技引用本文复制引用
秦颖超,周加义,朱敏,王修启..谷氨酸吸收转运及对肠道发育影响的研究进展[J].动物营养学报,2019,31(2):544-552,9.基金项目
国家自然科学基金重点项目(31330075) （31330075）
国家自然科学基金面上项目(31892389) （31892389）
广州市科技计划项目(201807010001) （201807010001）
