中国卒中杂志2019，Vol.14Issue(1)：33-37,5.DOI:10.3969/j.issn.1673-5765.2019.01.006
短暂性脑缺血发作和轻型卒中患者认知功能障碍与血清尿酸水平的相关性研究
Correlation between Cognitive Impairment and Serum Uric Acid Level in Patients with Transient Ischemic Attack or Minor Stroke
摘要
Abstract
Objective To investigate the relationship between serum uric acid level and cognitive impairment in patients with TIA/minor stroke. Methods The clinical and imaging data of 78 patients with TIA/minor stroke who were hospitalized in Shanghai Changhai hospital from June 2015 to June 2016. Patients were divided into cognitive impairment and no cognitive impairment group by using the Montreal cognitive assessment scale. The difference of serum uric acid levels between the two groups was tested by t test, and the relationship between serum uric acid level and cognitive impairment was analyzed by multivariate logistic regression analysis. Results A total of 78 patients with TIA/minor Stroke were enrolled, with 34 in cognitive impairment group and 44 in no cognitive impairment group. The prevalence of hypertension (70.6% vs 45.5%, P=0.026) and diabetes (52.9% vs 29.5%, P=0.036) in cognitive impairment group were higher than that in no cognitive impairment group. The serum uric acid level in cognitive impairment group [(0.31±0.07) mmol/L] was lower than that in no cognitive impairment group [(0.36±0.09) mmol/L], which was statistically significant (P=0.003). Serum uric acid level was an independent protective factor of cognitive impairment ( OR 0.990, 95% CI 0.984-0.997, P=0.008). Conclusions Compared with patients with no cognitive impairment, the patients with cognitive impairment had higher prevalence of diabetes and hypertension and lower serum uric acid level. Serum uric acid level was an independent protective factor of cognitive impairment.关键词
短暂性脑缺血发作/轻型卒中/认知功能障碍/尿酸Key words
Transient ischemic attack/Minor stroke/Cognitive impairment/Uric acid引用本文复制引用
孙旭,陈超,范存秀,黎佳思,毕晓莹..短暂性脑缺血发作和轻型卒中患者认知功能障碍与血清尿酸水平的相关性研究[J].中国卒中杂志,2019,14(1):33-37,5.基金项目
扬帆计划(XMLX201608)北京市首发基金(2016-2-2045)北京市医管局培育计划(PX2018021)国家自然科学基金(8173000716) （XMLX201608）
