现代医院2019，Vol.19Issue(2)：240-244,5.DOI:10.3969/j.issn.1671-332X.2019.02.024
肿瘤抗原SCCAg B细胞抗原表位及HLA Ⅰ类限制性CTL表位的生物信息学分析
Prediction of B cell Epitopes and HLA I Restricted CTL Epitopes Derived from Tumor Antigen SCCAg
摘要
Abstract
Ojbective To predicte the HLAⅠrestricted CTL epitopes and B cell antigen epitopes derived from tumor antigen SCCAg. Methods The linear B cell epitopes and conformational B cell epitopes of tumor antigen SCCAg were predicted by Ellipro program. In addition, the HLAⅠrestricted CTL epitopes of SCCAg were predicted by NetCTL, Prot-Param and so on. Results B cell epitopes analysis revealed that SCCAg had 10 potential linear B cell epitopes and 5 conformational B cell epitopes; Combined with peptide HLAⅠbinding, proteasomal C - terminal cleavage and TAP transport efficiency, the NetCTL predicts that multiple HLAⅠrestricted CTL epitopes were present in the tumor antigen SCCAg. Conclusion The B cell epitopes and HLAⅠrestricted CTL epitopes can be predicted by multiple methods, which may lay the foundation for the further research on immunotherapy for targeting SCCAg.关键词
SCCAg/B细胞表位/CTL表位Key words
SCCAg/ B Cell Epitopes/ CTL Epitopes分类
医药卫生引用本文复制引用
梁雪,胡腊,曾子成,林海,易高,刘兆宇..肿瘤抗原SCCAg B细胞抗原表位及HLA Ⅰ类限制性CTL表位的生物信息学分析[J].现代医院,2019,19(2):240-244,5.基金项目
国家自然科学基金青年基金项目(81400013) （81400013）
广东省教育厅特色创新项目(2016KTSCX110) （2016KTSCX110）
广州市科技计划项目(201804010018) （201804010018）
广州市黄埔区应用基础研究计划项目(201616) （201616）
