Inhibition of KU70 and KU80 by CRISPR interference, not NgAgo interference, increases the efficiency of homologous recombination in pig fetal fibroblastsOACSCDCSTPCD

作者：LI Guo-ling;LIU De-wu;WU Zhen-fang;CAI Geng-yuan;ZHANG Xian-wei;QUAN Rong;WANG Hao-qiang;RUAN Xiao-fang;MO Jian-xin;ZHONG Cui-li;YANG Hua-qiang;LI Zi-cong;GU Ting

作者单位：National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaWens Foodstuff Group Co., Ltd., Yunfu 527400, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaWens Foodstuff Group Co., Ltd., Yunfu 527400, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaWens Foodstuff Group Co., Ltd., Yunfu 527400, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.ChinaNational Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P.R.China

中文关键词：homologous recombinationnon-homologous end-joiningCRISPRiNgAgoi KU70 KU80

英文关键词：homologous recombinationnon-homologous end-joiningCRISPRiNgAgoi KU70 KU80

刊名：《农业科学学报（英文）》 2019 (2)

页码/页数：438-448,11

基金：We appreciate the technical assistance of the National Engineering Research Center for Breeding Swine Industry, Guangdong Wens Foodstuff Group Co., Ltd., Yunfu, China. This work was supported by the National Science and Technology Major Project for Breeding of New Transgenic Organisms, China (2016ZX08006002) and the Guangdong Province "Flying Sail Program" Postdoctoral Foundation, China (2016).

DOI：10.1016/S2095-3119(18)62150-1