国际医药卫生导报2019，Vol.25Issue(6)：903-905,3.DOI:10.3760/cma.j.issn.1007-1245.2019.06.019
两种二线方案治疗老年弥漫大B细胞淋巴瘤的临床观察
Clinical observation on two kinds of second-line treatment regimens for elderly diffuse large B-cell lymphoma
陈秀容 1郑艳彬 1邹思平 1王杰松 1王畅 1蔡勇君 1杨瑜 1吴晖 1何鸿鸣 1陈道光 1陈英 1林剑扬 1陈宁斌1
作者信息
- 1. 福建省肿瘤医院福建医科大学附属肿瘤医院肿瘤内科,福州 350014
- 折叠
摘要
Abstract
Objective To explore the clinical effect of two kinds of second-line treatment regimens for elderly diffuse large B-cell lymphoma (DLBCL).Methods A total of 96 elderly patients with DLBCL who were admitted to our hospital from July 2010 to July 2018 were selected as the subjects.The clinical data of the patients were retrospectively analyzed.Patients treated with R-ICE were included in control group (n=48),while those treated with R-GEMOX were included in observation group (n=48).The treatment effects were compared between the two groups.Results The response rate of the observation group was slightly higher than that of the control group (97.92％ vs.93.75％) (P＞0.05).The positive expression rates of FOXP1 and Livin in both groups decreased after treatment,and the positive expression rates of FOXP1 and Livin in the observation group were significantly lower than those in the control group (P＜0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group (10.42％ vs.27.08％) (P＜0.05).Conclusion The curative effect of R-GEMOX is better than R-ICE in the treatment of DLBCL.The former can significantly reduce the positive expression rates of FOXP 1 and Livin and the incidence of adverse reactions.关键词
R-ICE/R-GEMOX/老年/弥漫大B细胞淋巴瘤Key words
R-ICE/R-GEMOX/Elderly/Diffuse large B-cell lymphoma引用本文复制引用
陈秀容,郑艳彬,邹思平,王杰松,王畅,蔡勇君,杨瑜,吴晖,何鸿鸣,陈道光,陈英,林剑扬,陈宁斌..两种二线方案治疗老年弥漫大B细胞淋巴瘤的临床观察[J].国际医药卫生导报,2019,25(6):903-905,3.
