神经损伤与功能重建2019，Vol.14Issue(3)：113-115,131,4.DOI:10.16780/j.cnki.sjssgncj.2019.03.002
海南地区人群动脉硬化性脑梗死与PCK1启动子-232基因多态性的相关性研究
Re1ationship between Atherosc1erotic Cerebra1 Infarction and Po1ymorphism of Phosphoeno1. pyruvate Carboxykinase Gene Promoter-232 in Hainan Popu1ation
林树楷 1陈明磊 2高唯一 2林康b2
作者信息
- 1. 海南省第三人民医院,神经外科,海南,三亚,572000
- 2. 海南省第三人民医院,神经内科,海南,三亚,572000
- 折叠
摘要
Abstract
Objective: To exp1ore the re1ationship between atherosc1erotic cerebra1 infarction and po1ymor-phism of the phosphoeno1pyruvate carboxykinase gene (PCK1) promoter-232 in the Hainan popu1ation. Meth. ods: We recruited 160 patients with atherosc1erotic cerebra1 infarction as the observation group and another 160 hea1thy adu1ts who received check-ups during the same time as the contro1 group. PCK1 promoter-232 gene po1y-morphism was ana1yzed by po1ymerase chain reaction-restriction fragment 1ength po1ymorphism (PCR-RFLP);the carotid intima-media thickness and carotid artery p1aque (CAP) were detected by carotid dopp1er u1trasonog-raphy. The b1ood g1ucose and p1asma 1ipids were measured. Resu1ts: The 2 h postprandia1 b1ood g1ucose and LDL cho1estero1 1eve1s of the GC and GG genotypes in the observation group were higher than those of the CC genotype (F=12.811, 54.169, both P<0.001). Compared with that of the contro1 group, the frequencies of GC and GG genotypes and the G a11e1e in the observation group were significant1y higher ( χ2=13.341, 10.807, a11 P=0.001). With vu1nerab1e p1aques, the distribution of GC and GG genotypes and the G a11e1e in the observation group were significant1y 1arger than that with non-vu1nerab1e p1aques (χ2=5.186, 7.276, P=0.023, 0.007). The ca-rotid intima-media thickness of the 1eft and right carotid artery of different genotypes in the two groups were compared and showed no statistica1 difference (F=0.742, 0.485, 1.139, 0.727, P=0.478, 0.617, 0.325, 0.487). Conc1usion: There is a certain connection between PCK1 promoter-232 gene po1ymorphism and the occurrence of atherosc1erotic cerebra1 infarction in the popu1ation of Hainan, and the ro1e of G a11e1e is more prominent.关键词
脑梗死/PCK1/启动子/多态性Key words
cerebra1 infarction/ PCK1/ promoter/ po1ymorphism分类
医药卫生引用本文复制引用
林树楷,陈明磊,高唯一,林康b..海南地区人群动脉硬化性脑梗死与PCK1启动子-232基因多态性的相关性研究[J].神经损伤与功能重建,2019,14(3):113-115,131,4.
