中国卒中杂志Issue(2)：106-111,6.DOI:10.3969/j.issn.1673-5765.2019.02.004
脑白质疏松患者肾功能不全与血浆同型半胱氨酸的相关性研究
Relationship of Homocysteine with Renal Dysfunction in Patients with Leukoaraiosis
摘要
Abstract
Objective To examine the relationship of the level of plasma Hcy with renal dysfunction in patients with leukoaraiosis (LA). Methods According to the renal function, the patients were divided into renal dysfunction group (n=112) and normal control group (n=74). Demographic information such as sex, age, and past history were collected. The blood Cr, BUN, UA, Hcy, HbA1c, TC, LDL-C were measured. The degree of LA was measured by Fazekas scale according to MRI imaging. Results A total of 186 patients with LA were enrolled in this study. (1) The BUN (P=0.001), Cr (P=0.000), UA (P=0.000) and Hcy levels in renal dysfunction group were signiflcantly higher than those in control group (P=0.000), and the Fazekas score was signiflcantly higher than that of control group (P=0.04). (2) The correlation analysis showed that plasma Hcy level were positively correlated with the Fazekas score (r=0.202, P=0.027), the level of blood Cr (r=0.458, P=0.000), UA (r=0.229, P=0.010) and BUN (r=0.178,P=0.046). (3) Multivariate logistic regression analysis showed that plasma Hcy level ( OR 4.165, 95% CI 1.138-15.249, P=0.031) was an independent risk factor of renal dysfunction in patients with LA . Conclusions Plasma Hcy level may be an independent risk factor of renal dysfunction in patients with LA, and renal dysfunction may be involved in the development of LA by affecting blood Hcy level.关键词
脑白质疏松/肾功能不全/同型半胱氨酸Key words
Leukoaraiosis/Renal dysfunction/Homocysteine引用本文复制引用
徐畅,徐俊,张志宇,孙奕,黄丹青,王变荣..脑白质疏松患者肾功能不全与血浆同型半胱氨酸的相关性研究[J].中国卒中杂志,2019,(2):106-111,6.基金项目
江苏省自然科学基(BK20151592) （BK20151592）
