中国卒中杂志Issue(2)：121-126,6.DOI:10.3969/j.issn.1673-5765.2019.02.007
脂蛋白相关磷脂酶A2与脑梗死患者颈部动脉粥样硬化斑块的关系
The Relationship between Serum Lipoprotein-Associated Phospholipase A2 and hs-CRP Level and Carotid Artery Plaque in Patients with Cerebral Infarction
摘要
Abstract
Objective To investigate the relationship between serum lipoprotein-related phospholipase A2 (Lp-PLA2) and high-sensitivity C-reactive protein (hs-CRP) levels and carotid atherosclerotic plaque in patients with cerebral infarction. Methods 243 patients diagnosed with cerebral infarction in the Third People’s Hospital of Zhengzhou from January 2017 to March 2018 were selected as cerebral infarction group, and 120 subjects without cerebral infarction through physical examination in this hospital during the same period were selected as control group. Serum Lp-PLA2 and hs-CRP levels were detected in the two groups. According to the results of carotid artery ultrasound examination, the patients with cerebral infarction were divided into non-plaque group, stable plaque group and vulnerable plaque group. Results (1) Serum Lp-PLA2 level [(180.04±35.02) ng/mL vs (152.13±39.67) ng/mL, P=0.014] and hs-CRP level [(10.02±0.47) mg/L vs (2.64±0.33) mg/L, P=0.017] in cerebral infarction group were higher than those in control group. (2) Serum Lp-PLA2 level in the stable plaque group [(162.96±11.34) ng/mL vs (143.67±12.35) ng/mL, P=0.013] and vulnerable plaque group [(197.79±32.56) ng/mL vs (143.67±12.35) ng/mL, P=0.004] were both signiflcantly higher than that in the non-plaque group. Serum Lp-PLA2 level in vulnerable plaque group (P=0.007) was higher than that in stable plaque group. (3) Serum hs-CRP level in vulnerable plaque group were higher than that in stable plaque group [(12.86±1.67) mg/L vs (10.82±0.53) mg/L, P=0.029] and non-plaque group [(12.86±1.67)mg/L vs (9.54±0.47) mg/L, P=0.037] . Conclusions The serum Lp-PLA2 and hs-CRP level probably predicted the development and instability of carotid artery plaques in patients with cerebral infarction.关键词
脂蛋白相关磷脂酶A2/超敏C反应蛋白/脑梗死/动脉粥样硬化Key words
Lipoprotein associated phospholipase A2/Hypersensitive C-reactive protein/Cerebral infarction/Atherosclerotic引用本文复制引用
嵇朋,屈雪萍,周衡..脂蛋白相关磷脂酶A2与脑梗死患者颈部动脉粥样硬化斑块的关系[J].中国卒中杂志,2019,(2):121-126,6.基金项目
河南省科技攻关项目(182102310172) （182102310172）
