真空电子技术Issue(1)：14-20,7.DOI:10.16540/j.cnki.cn11-2485/tn.2019.01.04
纳秒电脉冲作用下KcsA-膜蛋白体系电穿孔的分子动力学模拟
Electroporation of KcsA Membrane Protein System under Nanosecond Pulsed Electric Field: a Molecular Dynamics Simulation
摘要
Abstract
Electroporation,electric field induced aqueous-filled pores of the cell membrane,is used widely in laboratories and increasingly in the clinic.The electroporation can be induced by vacuum electronic devices which can produce strong electromagnetic pulse.In order to study the molecular mechanism of electroporation of the KcsA membrane protein system,the whole process driven by nanosecond pulsed electric field with different amplitudesis simulatedby using molecular dynamics.It turns out that the electroporation formation time decreases with theincreasing magnitude of nanosecond pulsed electric field and pores are far away from the KcsA protein.A theoretical guidance for biomedical applications of electroporation is provided in this study.关键词
电穿孔/纳秒电脉冲/KcsA-膜蛋白体系/分子动力学/真空电子器件Key words
Electroporation/Nanosecond pulsed electric field/KcsA membrane protein/Molecular dynamics/Vacuum electronic device分类
信息技术与安全科学引用本文复制引用
唐靖超,殷海荣,马佳路,薄文斐,杨阳,徐进,宫玉彬..纳秒电脉冲作用下KcsA-膜蛋白体系电穿孔的分子动力学模拟[J].真空电子技术,2019,(1):14-20,7.基金项目
This work is supported by the National Science Foundation of China (Grant No.61531010). （Grant No.61531010）
