吉林大学学报（医学版）2019，Vol.45Issue(2)：400-404,5.DOI:10.13481/j.1671-587x.20190232
蛋白聚糖和ADAMTS-1在多囊卵巢综合征患者血清中的表达及其临床意义
Expressions of Versican and ADAMTS-1 in polycysticovary syndrome patients and their clincal significances
摘要
Abstract
Objective: To determine the expressions of Versican and a distintegrin and metalloprotease with thrombospondin type l motifs (ADAMTS-1) in serum in the polycystic ovary syndrome (PCOS) patients, and to clarify their roles in the pathogenesis of PCOS. Methods: A total of 80 patients with PCOS ( PCOS group) and 100 healthy women (control group) were selected. The heights and body weights of the subjects in two groups were measured; and the body mass index (BMI) was calculated. The levels of serum Versican and ADAMTS-1 of the subjects in two groups were measured by enzyme-linked immunosorbent assay (ELISA) method. The levels of serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), fasting blood glucose (FBG), fasting insulin of the subjects in two groups were detected; insulin resistance was evaluated according to Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The correlations between Versican, ADAMTS-1 and the metabolic indexes were analyzed by Pearson linear correlation analysis. Results: The serum Versican level of the patients in PCOS group was significantly decreased compared with control group (P=0.004); the serum ADAMTS-1 level was also decreased (P<0.01). The sensitivities, the specificities and the area under receiver operating characteristic (ROC) curve （AUC）of Versican and ADAMTS-1 in prediction of PCOS were 76.74%?vs 63.64% (P=0.018), 52.94% vs 40.73% (P=0.009) and 0675 (0.550-0.795) vs 0.714 (0.601-0.827) (P=0.032), respectively. The correlation analysis showed that in PCOS group the serum level of Versican of the patients was negatively correlated with FBG (r=-0.738, P=0.022), and ADAMTS-1 was negatively correlated with FBG (r=-0.524, P=0.043). Conclusion； Versican and ADAMTS-1 lowly express in the patients with PCOS. They are negatively correlated with the insulin resistance. They may play inhibitory effects in the occurrence of PCOS.关键词
蛋白聚糖/Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶/多囊卵巢综合征/胰岛素抵抗/空腹血糖Key words
Versican/ a distintegrin and metalloprotease with thrombospondin type 1 motifs/ polycystic ovary syndrome/ insulin resistance/ fasting blood glucose分类
医药卫生引用本文复制引用
金爱红1,周霞平2,余志英1..蛋白聚糖和ADAMTS-1在多囊卵巢综合征患者血清中的表达及其临床意义[J].吉林大学学报（医学版）,2019,45(2):400-404,5.基金项目
广东省科技厅自然科学基金资助课题(2015A020212001) （2015A020212001）
