中国免疫学杂志2019，Vol.35Issue(2)：207-212,6.DOI:10.3969/j.issn.1000-484X.2019.02.016
激酶LMTK3在前列腺癌组织中的表达及临床意义
Expression and clinical significance of LMTK3 in prostate cancer tissues
摘要
Abstract
Objective: To investigate the expression and clinical significance of LMTK3 in patients with prostate carcer. Methods: Immunohistochemistry was used to detect the expression of LMTK3 and ERα in 55 cases of prostate cancer tissues and 25 cases of benign prostatic hyperplasia tissues. The relationship between the expression of LMTK3 and ERα and clinicopathological parameters was evaluated by square test and Fisher exact test. The association between LMTK3 and ERα expression was analyzed with Pearson and Spearman rank correlation. Results: The results of immunohistochemistry demonstrated that the LMTK3 and ERα protein positive expression rate in 55 cases of prostate cancer tissues was 36. 36％ and 32. 73％, whereas was 64. 00％ and 56. 00％ in the benign prostatic hyperplasia, respectively, showed a significant difference of comparison within this result ( P ＜ 0. 05). The expression of LMTK3 in prostate cancer tissues was inversely related with the level of Gleason grade ( P＜0. 05), but no relation with the levels of age, TPSA, TNM stage and lymph node metastasis ( P＞0. 05). Moreover, the expression of ERα in prostate cancer tissues was oppositely related with the levels of gleason grade and TPSA ( P＜0. 05), but no relation with the levels of age, TNM stage and lymph node metastasis ( P＞0. 05). Pearson and Spearman rank correlation analysis revealed, to some extent, there was positively correlated with the two proteins ( r = 0. 296, P＜0. 05). Conclusion: The expression of LMTK3 in prostate cancer tissues was decreased compared with benign prostatic hyperplasia tissues and negatively related with the level of gleason grade. In some degree, there is a positively correlation between the LMTK3 and ERα proteins.关键词
LMTK3/ERα/前列腺癌/前列腺增生/免疫组织化学Key words
LMTK3/ERα/Prostate cancer/Benign prostatic hyperplasia/Immunohistochemistry分类
医药卫生引用本文复制引用
泮红飞,罗军敏,杨涛羽,苏俊,张红,龙润莹,冯继红..激酶LMTK3在前列腺癌组织中的表达及临床意义[J].中国免疫学杂志,2019,35(2):207-212,6.基金项目
国家自然科学基金项目 (81560407) （81560407）
贵州省科技厅社会发展攻关项目 (黔科合SY字[2015]3046号) （黔科合SY字[2015]3046号）
贵州省中医药管理局中医药、民族医药科学技术研究项目 (No.QZYY-2018-024) （No.QZYY-2018-024）
