中国免疫学杂志2019，Vol.35Issue(2)：240-243,4.DOI:10.3969/j.issn.1000-484X.2019.02.023
APOBEC3C的研究进展
Research on APOBEC3C
摘要
Abstract
APOBEC3 C is special as it has only weak antiviral functions and weakly restricts retroelements compared to other APOBEC3 s. APOBEC3 has only one cytidine deaminase domain which coordinates a zinc ion, and then is classified to A3 Z2 according to the amino acid specificity. APOBEC3 C induces less cytidine deamination in HIV-1 DNA than APOBEC3 G and has reduced ability to inhibit HIV-1 reverse transcription and integration compared to APOBEC3 G. APOBEC3 C induces G-to-A mutation that cannot block viral replications but contribute more to viral diversity. A single nucleotide polymorphism in human APOBEC3 C, a change from serine to isoleucine at position 188, results in increased enzymatic activity and potent antiviral activity against HIV-1. Dimerization of human APOBEC3 C increases the ability of continuous synthesis of single-stranded DNA, resulting in higher levels of mutation during reverse transcription in vitro and in cells. APOBEC3 C has evolved under positive selection in primates, and it is an important barrier that must be countered by the virus during natural infections. Therefore, research on APOBEC3 C may provide some ideas for anti-retroviral and anti-cancer therapeutic design.关键词
APOBEC3C/APOBEC3/HIV-1/VifKey words
APOBEC3C/APOBEC3/HIV-1/Vif分类
医药卫生引用本文复制引用
吴小霞..APOBEC3C的研究进展[J].中国免疫学杂志,2019,35(2):240-243,4.基金项目
海南省自然科学基金 (No.317163) （No.317163）
